Cell treatment apparatus and method

Surgery – Instruments – Light application

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

606 13, 606 17, 604 20, 604 21, 607 89, A61B 1732

Patent

active

052464377

ABSTRACT:
A catheter arrangement and associated method provides for the application of a cell treatment agent, such as genetic material or drugs to be inserted within the cells of a patient in vivo. The catheter arrangement uses an optical fiber having a prism at its tip. Laser energy from the optical fiber is directed by the prism through a window portion on a side of the catheter. The window portion has a plurality of holes so as to divide the laser energy into a plurality of microbeams. The microbeams porate cell walls of the patient's cells. A treatment agent channel in the catheter allows the treatment agent to be provided directly to the same holes through which the microbeams pass such that the treatment agent is very efficiently applied to the porations in the cell walls.

REFERENCES:
patent: Re31815 (1985-01-01), Alfano
patent: 4648892 (1987-03-01), Kittrell et al.
patent: 4686979 (1987-08-01), Gruen et al.
patent: 4748980 (1988-06-01), Cremer et al.
patent: 4785806 (1988-11-01), Deckelbaum
patent: 4860743 (1989-08-01), Abela
patent: 5041109 (1991-08-01), Abela
patent: 5061265 (1991-10-01), Abela et al.
"Gene Transfer Into Mammalian Cells By Rapid Freezing", Kiyoshi Sasaki et al., In Vitro Cell. Dev. Biol. 27A: pp. 86-88, Jan. 1991.
"High Efficiency Gene Transfection by Electroporation Using a Radio-Frequency Electric Field", Donald C. Chang et al., Biochimica et Biophysica Acta, 1992 (1991) pp. 153-160.
"Site Specific Gene Expression in Vivo by Direct Gene Transfer into the Arterial Wall", Elizabeth G. Nabel et al., Science, Sep. 14, 1990, pp. 1285-1288.
"Direct In Vivo Gene Transfer Into the Coronary and Peripheral Vasculatures of the Intact Dog", Chang S. Lim et al., Circulation, vol. 83, No. 6, Jun. 1991, pp. 2007-2011.
"Direct Gene Trasfer Into Human Cultured Cells Facilitated by Laser Micropuncture of the Cell Membrane", Wen Tao et al., Proc. Natl. Acam. Sci. USA, vol. 84, pp. 4180-4184, Jun. 1987.
"The Laser Method for Efficient Introduction of Foreign DNA into Cultured Cells", Shin-ichi Kurata et al., Experimental Cell Research 162, (1986), pp. 372-378.
"The Perforated Baloon Catheter: Assessment and Minimization of Arterial Trauma", JACC, vol. 19, No. 3, Mar. 1, 1992, 107A Charles Lambert and Timothy Grady.
"High-Velocity Microprojectiles for Delivering Nuclei Acids Into Living Cells", T. M. Klein, E. D. Wolf, F. Wu, & J. C. Sanford, Letters to Nature, vol. 327, May 7, 1987, pp. 70-73.
"Biolisitic Transformation: Microbes to Mice", S. A. Johnston, Nature, vol. 346, Aug. 23, 1990, pp. 776-777.
"Introduction of Foreign Genes Into Tissues of Living Mice By DNA-Coated Microprojectiles", R. Sanders Williams et al., Proc. Natl. Acad. Sci. USA, vol. 88, Apr. 1991, pp. 2726-2730, Genetics.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Cell treatment apparatus and method does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cell treatment apparatus and method, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cell treatment apparatus and method will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1046438

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.