Cell tray

Details Cell tray Cell tray

2007-03-13

2007-03-13

Toatley, Jr., Gregory J. (Department: 2877)

Optics: measuring and testing

Sample, specimen, or standard holder or support

Fluid containers

C356S326000

Reexamination Certificate

active

10693953

ABSTRACT:
A cell tray has a multi-dimensional array of cells in precise, equally spaced wells (cubicles or silos) containing medium of interest. The ordered cell array enables automated processing as well as simultaneous monitoring and analyzing of a large matrix of cells, biological fluids, chemicals and/or solid samples. The invention is an integrated device and is fabricated into substrates similar to microscope slides. The ordered array of cells in precise locations helps in parallel analysis and processing of cells simultaneously. Each cell cubicle or silo in the array is located equidistant from its nearest neighbors in an orthogonal direction. The location of each well can be precisely measured and recorded in an automated processing system. Included in the bottom of each cell well is an optional micro-lens. An array of probes provides parallel cell processing and monitoring capabilities, including microinjection and microscope analysis. The cell tray when integrated with the Precision Optical Intracellular Near Field Imaging/Spectroscopy Technology (POINT or NANOPOINT) device results in sub-wavelength high-resolution imaging with a nanosensor array capable of imaging inner regions of living cells without destroying its natural environment.

REFERENCES:
patent: 4415405 (1983-11-01), Ruddle et al.
patent: 5004307 (1991-04-01), Kino et al.
patent: 6208886 (2001-03-01), Alfano et al.
patent: 6238911 (2001-05-01), Kasahara
patent: 6519032 (2003-02-01), Kuebler et al.
patent: 6818907 (2004-11-01), Stark
patent: 2002/0173033 (2002-11-01), Hammerick et al.
patent: 2003/0020915 (2003-01-01), Schueller et al.
patent: 2003/0215844 (2003-11-01), Chapsky et al.
patent: 2005/0047971 (2005-03-01), Clements et al.
Milster et al.;Super-Resolution by Combination of a Solid Immersion Lens and Aperture; The Japanese Society of Applied Physics, Part 1, No. 3B: Mar. 2001.
Hecht et al.;scanning near-field optical microscopy with aperture probes: Fundamentals and applications; Special Topic: Near-field Microscopy and Spectroscopy: Journal of Chemical Physics; vol. 112, No. 18; May 8, 2000.
Betzig & Chichester;Single Molecules Obseerved by Near-field Scannning Optical Microscopy; Science, New Series; vol. 262, No. 5138; Nov. 26, 1993; pp. 1422-1425.
Mansfield & Kino;Solid Immersion Microscope; Appl. Physics Letter; vol. 57, No. 24; Dec. 10, 1990.
D. V. Palanker et al.;On contrast parameters and topographic artifacts in near-field infrared microscopy; Journal of Applied Physics, vol. 88, No. 11; Dec. 1, 2000.
Tom D. Milster et al.;The Nature of the Coupling field in Optical Data Storage using Solid Immersion Lenses; The Japanese Society of Applied Physics, Part 1, No. 3B: Mar. 1999.
Jonathan D. Bui et al.;Probing intracellular dynamics in living cells with near-field optics; Journal of Neuroscience Methods 89 (1999) 9-15; Feb. 27, 1999.
Tang et al.;Consideration and control of writing conditions with a near-field APSIL probe; Proceedings of International Symposium on Optical Memory and Optical Data Storage/2002; ISBN 0-7803-7379-0; Published:2002; pp. 243-245.

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