Cell surface receptor complementation

Details Cell surface receptor complementation Cell surface receptor complementation

1995-11-03

1997-08-19

Woodward, Michael P.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 71, 435 721, 436501, 436547, G01N 33567, G01N 33566, G01N 33531, G01N 3353

Patent

active

056587465

ABSTRACT:
A method of controlling the amount of a biologically active substance binding to a cell surface having both receptors to the substance and receptors for the Fc domain of an antibody that can complex with the substance or other antibodies that can complex with the substance. By exploiting the generally more numerous Fc receptor sites, substance binding can be increased and/or controlled. Method contemplates controlling amounts of substances such as cytokines, hormones, and growth factors that are associated with cells such as monocytes, macrophages, granulocytes, B cells, T cells, and platelets. Method is illustrated using conjugated antibodies to tissue necrosis factor (TNF) to increase the binding of TNF to monocytes.

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Porter, A.G., "The Prospects for Therapy with Tumor Necrosis Factors and Their Antagonists," Trends Biotechnology 9:158-162. (1991).

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