Chemistry: molecular biology and microbiology – Apparatus – Differentiated tissue perfusion or preservation apparatus
Patent
1990-08-24
1993-06-08
Wityshyn, Michael G.
Chemistry: molecular biology and microbiology
Apparatus
Differentiated tissue perfusion or preservation apparatus
435285, 435316, C12M 300
Patent
active
052178994
ABSTRACT:
Disclosed is an apparatus and method for imparting to a living culture of cells biaxial mechanical forces which approximate the mechanical forces to which cells are subjected in vivo. The apparatus includes a displacement applicator which may be actuated to contact and stretch a membrane having a living cell culture mounted thereon. Stretching of the membrane imparts biaxial mechanical forces to the cells. These forces may be uniformly applied to the cells, or they may be selectively non-uniformly applied.
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"Characterization of The Surface Strain Applied to Cyclically Stretched Cells In Vitro", Gilbert et al, 35th Annual Meeting, Orthopaedic Research Society, Feb. 6-9, 1989, Las Vegas, Nev. (p. 249).
"Think About A Novel Method For Culturing Cells In A Mechanically Active Environment", A brochure of the Flexcell Corp., McKeesport, Pa. 15132 (1-412-664-FLEX).
"Introducing the Vitrodyne A New Force In Cell and Tissue Culture", A brochure from Biomechanical Instruments of Burlington, Vt. 05401.
Gray Martha L.
Melendez Luis A.
Schaffer Jonathan L.
Shapiro Alan R.
Venegas Jose G.
Beisner William A.
Massachusetts Institute of Technology
The General Hospital Corporation
Wityshyn Michael G.
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