Cell strain capable of multiplying an Epstein-Barr virus

Details Cell strain capable of multiplying an Epstein-Barr virus Cell strain capable of multiplying an Epstein-Barr virus

1994-08-24

1996-07-09

Wityshyn, Michael G.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4352351, 435239, C12N 500, C12N 701, C12N 702

Patent

active

055344305

ABSTRACT:
The present invention relates to a cell strain capable of separating and multiplying an EB virus and derived from human lymphocyte cancer cells and a method of separating and multiplying the EB virus by means of said cell strain. The present cell strain can be applied to the separation and multiplication of the wild type virus present in various places, as well as to the separation and multiplication of the virus produced by homologous recombination etc. The virus newly separated and multiplied can be applied to vaccine etc. For the more efficient separation and multiplication of the virus, several markers can be inserted into the present cell strain.

REFERENCES:
patent: 4692405 (1987-09-01), Freedman et al.
patent: 4916072 (1990-04-01), Tsyi et al.
patent: 5316920 (1994-05-01), Tedder et al.
"Epstein-Barr Virus (EBV)-Negative B-Lymphoma Cell Lines for Clonal Isolation and Replication of EBV Recombinants".
Marchini, Andrew; Longnecker, Richard; Kieff, Elliott. Journal of Virology, Aug. 1992, p. 4972-4981.
Takada et al., Virus Genes 5:2, 147-156 (1991).
Daibata et al., Virology 196, 900-904 (1993).
Daibata et al., FASEB Journal 4:7, p. A1721, Abstract 154 (1990).

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