Cell specific, variable density, polymer microspheres

Details Cell specific, variable density, polymer microspheres Cell specific, variable density, polymer microspheres

1977-02-03

1978-08-08

Foelak, Morton

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Cellular products or processes of preparing a cellular...

260 8, 260112R, 260112B, 428402, 526229, 526245, 526250, 526296, 526909, 195 65, C08F22600, C08F21800

Patent

active

041055985

ABSTRACT:
Biocompatible polymeric microspheres having an average diameter below about 3 microns and having a density at least 15% greater or lesser than organic cells and having covalent binding sites are provided in accordance with this invention. The microspheres are obtained by copolymerizing a hydroxy or amine substituted acrylic monomer such as hydroxyethylmethacrylate with a light or dense comonomer such as a fluoromonomer. A lectin or antibody is bound to the hydroxy or amine site of the bead to provide cell specificity. When added to a cell suspension the marked bead will specifically label the cell membrane by binding to specific receptor sites thereon. The labelled membrane can then be separated by density gradient centrifugation.

REFERENCES:
patent: 3775253 (1973-11-01), Dieter et al.
patent: 3847745 (1974-11-01), Axen et al.
patent: 3871964 (1975-03-01), Huper et al.
patent: 3957741 (1976-05-01), Rembaum et al.
patent: 3985632 (1976-10-01), Rembaum et al.

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