Cell specific, variable density, polymer microspheres

Details Cell specific, variable density, polymer microspheres Cell specific, variable density, polymer microspheres

1975-11-24

1977-07-12

Foelak, Morton

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

260 8, 260 465UA, 260 63HA, 260 63N, 260 63BB, 260 65, 526225, 526229, 526245, 526251, 526279, 526296, 526303, 526306, 526307, 526317, 526320, 526328, 526329, C08J 916

Patent

active

040353168

ABSTRACT:
Biocompatible polymeric microspheres having an average diameter below about 3 microns and having density at least 15% greater or lesser than organic cells and having covalent binding sites are provided in accordance with this invention. The microspheres are obtained by copolymerizing a hydroxy or amine substituted acrylic monomer such as hydroxyethylmethacrylate with a light or dense comonomer such as a fluoromonomer. A lectin or antibody is bound to the hydroxy or amine site of the bead to provide cell specificity. When added to a cell suspension the marked bead will specifically label the cell membrane by binding to specific receptor sites thereon. The labelled membrane can then be separated by density gradient centrifugation.

REFERENCES:
patent: 3957741 (1976-05-01), Rembaum et al.

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