Cell-specific gene therapy using as promoter novel promoters for

Details Cell-specific gene therapy using as promoter novel promoters for Cell-specific gene therapy using as promoter novel promoters for

1996-07-12

1998-12-29

Low, Christopher S. F.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 691, 4351723, 4353201, 435325, 435 914, 424 9321, 536 231, 536 234, C12N 121

Patent

active

058540199

ABSTRACT:
The invention relates to promoter sequences for a gene comprising a tissue inhibitor of metalloproteinase-3 (TIMP-3). This inhibitor is found in particular in macrophages, synovial cells, and connective tissue cells. The invention also relates to cell-specific gene therapy of a subject, wherein expression of a gene in a tissue is regulated by the aforementioned promoter sequence operationally coupled to said gene. The promoter may also be used in diagnostic methods.

REFERENCES:
Nordeen Luciferase Reporter Gene Vectors for Analysis of Promoters and Enhancers, Bio Techniques vol. 6 No. 5 (1988).
Wick Structure of the human TIMP-3 gene and its cell cycle-regulated promoter Biochem J. 311:549-554 (1995).
Mullen, et al. Metabolic Suicide Genes in Gene Therapy, Pharmac. Ther. 63:199-207 (1994).
Harris, et al. Gene therapy for cancer using tumour-specific prodrug activation, Gene Therapy 1:170-175 (1994).
Wick, et al. A Novel Member of Human Tissue Inhibitor of Metalloproteinases (TIMP) Gene Family Is Regulated during G.sub.1 Progression, Mitogenic Stimulation, Differentiation, and Senescence Journal biol.Chem. vol. 269 No. 29:18953-18960 (1994).
Lucibello, et al. Sensitive Microscale Assay for the Analysis of Promoter Activity in Eukaryotic Cells, MMCB vol. 1 No. 1:9-18 (1989).
Angel, et al. 12-O-Tetradecanoyl-Phorbol-13-Acetate Induction of the Human Collagenase Gene Is Mediated by an Indicible Enhancer Element Located in the 5'-Flanking Region, Molec.Cell.Biol. vol. 7, No. 6:2256-2266 (1987).
Setoyama, et al. Transcriptional activation encoded by the V-fos gene, Proc.Natl.acad.Sci. USA 83:3213-3217 (1986).
Herber, et al. Inducible regulatory in the human cyclin D1 promoter, Oncogene 9:1295-1304 (1994).
Webster's II New Riverside University Dictionary, 1994, p. 67.
Clerclz et al., Gene 139, 185-191, 1994.
Apte, Genomics 19, 86-96, 1994.

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