Cell specific gene regulators

Details Cell specific gene regulators Cell specific gene regulators

1992-08-03

1994-02-22

Wax, Robert A.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

4352402, 4353201, 536241, 935 6, 935 33, 935 34, 935 36, C12N 1585, C12N 1567, C12N 516, C07H 2104

Patent

active

052888460

ABSTRACT:
Methods and compositions for cell-specific expression of genes are provided. The invention utilizes the endothelin-1 promoter and promoter elements to direct expression of heterologous genes in endothelial cells. The promoters and elements are useful for directing cell-specific expression of therapies for vascular and cardiovascular diseases.

REFERENCES:
D. B. Wilson, et al. (1990) Molecular & Cellular Biology 10:4854-4862.
M. --E. Lee, et al., (1990) Journal of Biological Chemistry 265:10446-10450.
K. D. Bloch, et al. (1989) Journal of Biological Chemistry 264:10851-10857.
A. Inoue, et al. (1989) Journal of Biological Chemistry 264:14954-14959.
A.--J. van Zonneveld, et al. (1988) Proc. Natl. Acad. Sci., USA 85:5525-5529.
J. M. Wilson, et al. (1989) Science 244:1344-1346.
Beato, M. Cell 56:335-344 (1989).
Berliner et al., Blood 67(4):914-918 (1986).
Bodner et al., Cell 55:505-518 (1988).
Boulet et al., Proc. Natl. Acad. Sci. USA 83:3599-3603 (1986).
Dialynas et al., Proc. Natl. Acad. Sci. USA 83:2619-2623 (1986).
Dignam et al., Nucleic Acids Research 11(5):1475-1489 (1983).
Dynan, W. S. Cell 58:1-4 (1989).
Evans et al., Cell 58:877-885 (1989).
Frain et al., Cell 59:145-157 (1989).
Ingraham et al., Cell 55:519-529 (1988).
Inoue et al., Proc. Natl. Acad. Sci. 86:2863-2867 (1989).
Leiden et al., Immunogenetics 27:231-238 (1988).
Maniatis et al., Science 236:1237-1245 (1987).
Paigen et al., Atherosclerosis 57:65-73 (1985).
Russell et al., J. Biol. Chem. 205(5):2569-2575 (1990).
Strauss et al., Science 237:1217-1219 (1987).
Takuwa et al., J. Biol. Chem. 264(14):7856-7861 (1989).
Tsai et al., Nature 339:446-451 (1989).
Yanagisawa et al., Nature 332:411-415 (1988).
Zweibel et al., Science 243:220-222 (1989).

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