Cell-specific adenovirus vector comprising EBV-specific...

Details Cell-specific adenovirus vector comprising EBV-specific... Cell-specific adenovirus vector comprising EBV-specific...

2008-05-13

2008-05-13

Guzo, David (Department: 1636)

Chemistry: molecular biology and microbiology

Vector, per se

C435S325000, C536S023100, C536S024100

Reexamination Certificate

active

10698160

ABSTRACT:
Replication-competent adenoviral vectors comprising an EBV-specific transcriptional regulatory element (TRE) operably linked to a gene required for adenovirus replication are provided. By providing for transcriptional initiating regulation dependent upon transcription factors that are only active in specific, limited cell types, virus replication can be restricted to particular target cells. The modified adenovirus may be used as a vehicle for introducing new genetic capability, particularly associated with cytotoxicity for treating neoplasia.

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