Cell seeding of ceramic compositions

Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Implantable prosthesis – Bone

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A61F 228

Patent

active

061324639

ABSTRACT:
The present invention provides a synthetic, poorly-crystalline apatitic (PCA) calcium phosphate material seeded with cells. Preferably, the cells are tissue-forming or tissue-degrading cells. The compositions provided by the present invention are useful for a variety of applications, including in vivo and in vitro tissue growth (preferably bone or cartilage), osseous augmentation, and methods of diagnosing disease states by assaying tissue-forming potential of cells isolated from a host. The invention also provides in vitro cell culture systems and cell encapsulation matrices.

REFERENCES:
patent: 5516532 (1996-05-01), Atala et al.
patent: 5522893 (1996-06-01), Chow et al.
patent: 5665120 (1997-09-01), Ohtsuka et al.
patent: 5700289 (1997-12-01), Brietbart et al.

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