Cell proliferation inhibitor and method of preparation

Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus

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A61K 3544

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active

045349673

ABSTRACT:
An inhibitor of endothelial cell growth is prepared by directly liquifying vitreous gel, as for example, forcing vitreous gel through a small orifice so as to directly convert the gel into a liquid, removing insoluble and suspended material and chromatographically fractionating the liquid and isolating the fractions. An inhibitor is also prepared by culturing hyalocyte cells in a medium and chromatographically fractionating the medium.

REFERENCES:
patent: Re30239 (1984-05-01), Kuettner et al.
patent: 3864084 (1984-05-01), Folkman
patent: 4042457 (1984-05-01), Kuettner et al.
patent: 4164560 (1984-05-01), Folkman et al.
patent: 4176177 (1984-05-01), Kuettner
patent: 4217412 (1984-05-01), Tolbert et al.
Guedon et al.--Chem. Abst., vol. 95 (1981) p. 156,572 K.
Raymond et al.--ARVO abst. (Apr. 1980), abst 8-10:15, pp. 145-146.
Jacobson et al.--ARVO abst., (Mar. 1981), abst. 46 p. 216.
"Isolation and Identification of Stimulatory and Inhibitory Cell Growth in Bovine Vitreous", Laurie Raymond and Bernard Jacobson, Exp. Eye Res. (Feb. 1982) 34.000-00.

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