Cell proliferation inhibitor and method of preparation

Details Cell proliferation inhibitor and method of preparation Cell proliferation inhibitor and method of preparation

1986-02-12

1987-12-01

Rosen, Sam

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

435212, 435219, 435226, 530350, 514 2, C12P 2100

Patent

active

047104627

ABSTRACT:
This invention comprises preparing a cell proliferation inhibitor by a nonextractive method from a tissue which has neither a high content of collagen, nor proteoglycans. The source of inhibitor comprises hyalocyte cells, which release the inhibitor into culture medium. The inhibitor is isolated from the culture medium. By chromatographic separation fractions are provided of varying molecular weight. Fractions both below and above a molecular weight of about 13,000 daltons show inhibitory activity.

REFERENCES:
Raymond et al.-ARVO Abst., (Apr. 1980), Abst. 8-10:15, pp. 145-146.
Jacobson et al., ARVO Abst., (Mar. 1981), Abst. 46, p. 216.

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