Cell permeable peptide

Details Cell permeable peptide Cell permeable peptide

2011-08-02

2011-08-02

Stoica, Elly-Gerald (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

C530S327000, C514S001300, C435S069700

Reexamination Certificate

active

07989588

ABSTRACT:
The number of peptides having an ability to bind to a cell or penetrate into a cell is narrowed down by being selectively enriched from a random peptide library with a diversity of not less than one hundred millions of peptides using a phage surface display technique, and then cytoplasmic transfer is evaluated by using protein synthesis inhibition as an indicator by adding to a cell, a fusion body of the selectively enriched peptide and a protein synthesis inhibitory factor (PSIF) that cannot solely penetrate into the cell.

REFERENCES:
patent: 2003/0113819 (2003-06-01), Horton et al.
patent: H10-33186 (1998-02-01), None
patent: 2001-199997 (2001-07-01), None
patent: WO 94/04686 (1994-03-01), None
patent: WO01/41811 (2001-06-01), None
Suzuki et al., “Characteristics of Membrane Permeable Arginine-Rich Peptides,”Peptide Sequence 2000, The Japanese Peptide Society, pp. 89-92.

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