Cell migration assay

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S007200, C435S007210, C435S007800, C530S350000, C530S399000

Reexamination Certificate

active

11788334

ABSTRACT:
The present invention is directed to a modified cell migration assay allowing for improved identification and discrimination of chemokine receptor antagonists from non-specific blockers.

REFERENCES:
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 6448054 (2002-09-01), Poznansky et al.
patent: 6451522 (2002-09-01), LaRosa
patent: 6689570 (2004-02-01), Andrew
patent: 6884574 (2005-04-01), Andrew
patent: 7282338 (2007-10-01), Wei et al.
patent: WO 97/31949 (1997-09-01), None
patent: WO 98/09171 (1998-03-01), None
Ali et al. Chemoattractant Receptor Cross-desensitization. The Journal of Biological Chemistry, vol. 274, No. 10, pp. 6027-6030 (1999).
2003/0166143 A1.
Ancelin et al., “Vascular Endothelial Growth Factor VEGF189 Induces Human Neutrophil Chemotaxis In Extravascular Tissue Via An Autocrine Amplification Mechanism,”Laboratory Investigation, 84:502-512 (Feb. 16, 2004).
Ausubel, F.M., R. Brent, R.E. Kingston, D.D. Moore, et al., “Current Protocols in molecular biology,”John Wiley&Sons, New York (1987).
Bacon, K.B. et al., “Contrasting in vitro lymphocyte chemotactic activity of the hydroxyl enantiomers of 12-hydroxy-5, 8, 10, 14-eicosatetraenoic acid,”Br. J. Pharmacol., 95:966-974 (1988).
Baggiolini et al.,Annu. Rev. Immunol, 15:675-705 (1997).
Baggiolini et al.,Advances in Immunology, 55;97-179 (1994).
Behar et al., “Neurotrophins Stimulate Chemotaxis of Embryonic Cortical Neurons,”European Journal of Neuroscience, 9:2561-2570 (Jun. 18, 1997).
Deng, et al.,Nature, 381:661-666 (1996).
Ellington, A.D., et al., “In vitro Selection of RNA Molecules that Bind Specific Ligands,”Nature, 346:818-822 (1990).
Ernst et al., An Annexin 1 N-Terminal Peptide Activates Leukocytes by Triggering Different Members of the Formal Peptide Receptor Family,Journal of Immunology, 172:7669-7676 (Apr.6, 2004).
Nakamura et al., “Signals Via FGF Receptor 2 Regulate Migration of Endothelial Cells,”Biochemical and Biophysical Research Communications, 289:801-806 (Nov. 9, 2001).
Penfold, M. E. et al., “Cytomegalovirus Encodes a Potent Alpha Chemokine,”Proc. Natl. Acad. Sci. USA, 96:9839-9844 (1999).
Polk et al., “Epidermal and Hepatocyte Growth Factors Stimulate Chemotaxis in an Intestinal Epithelial Cell Line,”Am J. Physiol., 277:C1149-CI159 (1999).
Postma et al., “Chemotaxis Inhibitory Protein ofStaphylococcus aureusBinds Specifically to the C5a and Formylated Peptide Receptor,”Journal of Immunology, 172:6994-7001 (Mar. 18, 2004).
Rosenfeldt et al., “The Sphingosine-I-Phosphate Receptor EDG-I is Essential for Platelet-Derived Growth Factor-Induced Cell Motility,”Biochemical Society Transactions, 29(6):836-839 (Jun. 30, 2001).
Riechmann, L., M. Clark, H. Waldmann, G. Winter, “Reshaping Human Antibodies for Therapy,”Nature. 332-323-7 (1988).
Rossi, D., and A. Zlotnik, “The Biology of Chemokines and their Receptors,”Annu. Rev. Immunol., 18:217-242 (2000).
Schratzberger et al., “Differential Chemotactic Activities of Sensory Neurpeptides for Human Peripheral Blood Mononuclear Cells”Journal of Immunology, 158:3895-3901 (Jan. 13, 1997).
Serhan et al., “Cutting Edge: Nociceptin Stimulates Neutrophil Chemotaxis and Recruitment. Inhibition byAspirin-Triggered-15-Epi-Lipoxin A4,”Journal of Immnology, 166:3650-3654 (Jan. 19, 2001).
Shizukuda et al., “Vascular Endothelial Growth Factor-Induced Endothelial Cell Migration and Proliferation Depend on a Nitric Oxide-Mediated Decrease in Proteine Kinase Co Activity,”Circ. Res., 85:247-256 (Aug. 6, 1999).
Song et al., “CB1 Cannabinoid Receptor-Mediated Cell Migration,”Journal of Pharmacology and Experimental Therapeutics, 294(1):204-209 (Mar. 22, 2000).
Tager et al., “Leukotriene B4 Receptor BLT1 Mediates Early Effector T Cell Recruitment,”Nature Immunology, 10(4):982-990 (Oct. 2003).
Tuerk, C. et al., “Systemic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase,”Science, 249:505-510 (1990).
Verhoeyen, M., C. Milstein, and G. Winter, “Reshaping Human Antibodies: Grafting an Antilysozyme Activity.”Science, 239:1534-6 (1988).
Yule et al., “Migration of 3T3 and Lung Fibroblasts in Response to Calcitonin Gene-Related Peptide and Bombesin,”Experimental Lung Research, 25:261-273 (Aug. 5, 1998).
Zhang et al., “VEGF is a Chemoattractant for FGF-2-Stimulated Neural Progenitors,”Journal of Cell Biology, 163(6): 1375-1384 (Dec. 22, 2003).
Fiedler et al., “To Go or Not to Go: Migration of Human Mesenchymal Progenitor Cells Stimulated by Isoforms of PDGF,”Journal of Cellular Biochemistry, 93:990-998 (May 26, 2004).
Forster, R., et al., “CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs”,Cell, 99; 23-33 (1999).
Gutzmer et al., “Human Monocyte-Derived Bendritic Cells Are Chemoattracted to C3a After Up-Regulation of the C3a Receptor with Interferons,”Immunology, 111:435-443 (Jan. 9, 2004).
Haynes et al., “Inhibition of C5a-Induced Neutrophil Chemotaxis and Macrophage Cytokine Production in Vitro by a New C5a Receptor Antagonist,”Biochemical Pharmacology, 60:729-733 (Mar. 13, 2000).
Hesselgesser et al.,J Biol Chem, 273(25):15687-92 (1998).
Horuk,Trends Pharm. Sci., 15:159-165 (1994).
Idzko et al., “Nucleotides Induce Chemotaxis and Actin Polymerization in Immature But Not Mature Human Dendritic Cells Via Activation of Pertussis Toxin-Sensitive Pty Receptors,”Immunobiolo, 100(3):925-932 (Mar. 13, 2002).
Jayasena, S.D. ,“Aptamers: An Emerging Class of Molecules that Rival Antibodies in Diagnostics,”Clin Chem. 45:1628-50 (1999).
Jones, P.T., P.H. Dear, J. Foote, M.S. Neuberger, et al., “Replacing the Complementarity-determining Regions in a Human Antibody with Those from a Mouse,”Nature, 321:522-5 (1986).
Kledal, T.N. et al, “A Broad-spectrum Chemokine Antagonist Encoded by Kaposi's Sarcoma-associated Herpesvirus,”Science, 277:1656-1659 (1997).
Klein et al., “Identification of Surrogate Agonists for the Human FPLR-1 Receptor by Autocrine Selection in Yeast,”Nature Biotechnology, 16:1334-7 (1998).
Lamb et al., “EGF Mediates Monocyte Chemotaxis and Macrophage Proliferation and EGF Receptor is Expressed in Atherosclerotic Plaques,”Atherosclerosis, 176:21-26 (Apr. 20, 2004).
Ling et al., “Histamine H4 Receptor Mediates Eosinophil Chemotaxis with Cell Shape Change and Adhesion Molecule Upregulation,”British Journal of Pharmacology, 142:161-171 (Feb. 9, 2004).
Loetscher et al., “The Ligands of CXC Chemokine Receptor 3, I-TAC, Mig, and IP10, Are Natural Antagonists for CCR3”,J. Biol. Chem., 276(5):2986:91 (2001).
Migeotte et al., “Identification and Characterization of an Endogenous Chemotactic Liquid Specific for FPRL2,”Journal of Experimental Medicine, 201(1):83-93 (Jan. 3, 2005).
Mimura et al., “Inhibitory Effect of the 4 Aminotetrahydroquinoline Derivatives, Selective CRTH2 Antagonists, on Eosinophil Migration Induced by Prostaglandin D2,”Journal of Pharmacology and Experimental Therapeutics, as DOI:10.1124 et. 104.081539 (Mar. 29, 2005).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Cell migration assay does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cell migration assay, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cell migration assay will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3958062

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.