Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1998-06-05
2000-08-08
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
424 943, 935 54, A61K 9127, A61K 9133
Patent
active
060998571
ABSTRACT:
A lipid vesicle composition for use in delivering a vesicle-encapsulated agent to a target cell is disclosed. The composition is formed of vesicle-forming lipids, including at least 10 mole percent plasmalogen phospholipid with a small-volume polar head group. The composition may also include a fusion protein for promoting fusion of the vesicles to the target cells. A novel fusion protein identified as an isoform of glyceraldehyde-3-phosphate dehydrogenase is also disclosed.
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Dehlinger Peter J.
Kishore Gollamudi S.
Mohr Judy M.
Washington University
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