Cell matrix receptor system and use in cancer diagnosis and mana

Details Cell matrix receptor system and use in cancer diagnosis and mana Cell matrix receptor system and use in cancer diagnosis and mana

1983-04-04

1986-01-21

Marantz, Sidney

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

Utilizing isolate of tissue or organ as binding agent

260112R, 435 23, 435 69, 436 63, 436501, 436503, 436519, 436808, 436813, G01N 33566, G01N 3350, G01N 33534, G01N 33567

Patent

active

045657890

ABSTRACT:
A cell matrix receptor specific for laminin expressed on the surface of carcinoma and epithelial cells is provided. The binding of these cells to extracellular matrix is mediated by the laminin molecule, which has binding domains for type IV collagen of the matrix and the cell surface receptor. Fragments of the laminin molecule lacking the type IV collagen binding domain and antibodies to the receptor are useful in conjunction with the cell receptor as ligands in binding assays for cancer diagnosis and in cancer management.

REFERENCES:
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patent: 4340581 (1982-07-01), Timpl
patent: 4383985 (1983-05-01), Bartorelli
V. P. Terranova et al., Proc. Natl. Acad. Sci. USA, 80 (2), 444-448 (1983).
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C. N. Rao et al., I, Arch. Biochem. Biophys., 219 (1), 65-70 (1982).
C. N. Rao et al., II, J. Biol. Chem., 257 (16), 9740-9744 (1982).

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