Cell lysis activity of a modified fragment of the glucocorticoid

Details Cell lysis activity of a modified fragment of the glucocorticoid Cell lysis activity of a modified fragment of the glucocorticoid

1993-07-02

1995-11-21

Draper, Garnette D.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352401, 4352523, 4353201, 435 694, 536 235, C12N 1516

Patent

active

054686245

ABSTRACT:
A cell lysis factor which is a modified fragment of the human glucocorticoid receptor. The modified fragment designated 398-465*, when transfected into and expressed in a host cell, effects cell lysis and cell death. A pharmaceutical composition having the modified fragment 398-465* or the encoded protein product may be used in treatment of proliferative diseases.

REFERENCES:
Giguere et al., "Functional Domains of the Human Glucocorticoid Receptor," Cell, 46:645-652, 1986, published in USA.
Harbour et al., "Steroid Mediated Lysis of Lymphoblasts Requires the DNA Binding Region of the Steroid Hormone Receptor," J. Steroid Biochem., 35(1):1-9, 1990, published in USA.
Hollenberg et al., "Primary Structure and Expression of a Functional Human Glucocorticoid Receptor cDNA," Nature, 318:635-641, 1985, published in Europe.
Hollenberg et al., "Colocalization of DNA-Binding and Transcriptional Activation Functions in the Human Glucocorticoid Receptor," Cell, 49:39-46, 1987, published in USA.
Nazareth et al., "Mapping the Human Glucocorticoid Receptor for Leukemic Cell Death," J. Biol. Chem., 266(26):12976-12980, published in USA.
Thompson et al., "Glucocorticoids in Malignant Lymphoid Cells: Gene Regulation and the Minimum Receptor Fragment for Lysis," J. Steroid Biochem. Molec. Biol., 43(3-8):273-282, 1992, published in Europe.

Affiliated with

Also associated with

Rating

Cell lysis activity of a modified fragment of the glucocorticoid does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cell lysis activity of a modified fragment of the glucocorticoid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cell lysis activity of a modified fragment of the glucocorticoid will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1136217