Cell lines useful for in vitro assay for indentification of carc

Details Cell lines useful for in vitro assay for indentification of carc Cell lines useful for in vitro assay for indentification of carc

1997-10-16

2000-11-28

Wortman, Donna

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435354, 435357, 435366, 435 723, C12N 506, C12N 508, C12N 510

Patent

active

061534293

ABSTRACT:
Disclosed test cells are useful for evaluating the carcinogenicity of a compound using a transformation assay. The test cell preferably is transfected with an oncogenic viral recombinant nucleic acid molecule encoding a transforming protein. Cell growth is scored to identify the presence or absence of a transformation characteristic, such as formation of foci, loss of growth factor or serum requirements or anchorage independence. The development of such a transformation characteristic indicates that the compound being tested is carcinogenic.

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