Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1995-06-07
1998-09-22
Nucker, Christine M.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
4352401, 43524021, 435974, C12N 510
Patent
active
058112820
ABSTRACT:
The present invention relates to a method for AIDS diagnosis and monitoring of anti-AIDS drug therapy, and more particularly to a method of assaying for human immunodeficiency virus. The present invention uses a focal immunoassay (FIA) which utilizes HIV-specific antibodies and indirect immunoassay techniques to detect local areas of HIV infection in susceptible target cells growing in monolayers on plastic dishes. The present invention further relates to specific cell lines used as the susceptible target cells in the disclosed methods.
REFERENCES:
Maddon et al: The T4 Gene Encodes the AIDS Virus Receptor and is Expressed in the Immune System and the Brain, Cell, v.47, pp. 333-348 Nov. 7, 1986.
Stanley. "Membrane Mutants of Animal Cells Rapid Identification of Those with a Primary Defect in Glycosytation" Molecular & Cell. Biol. V5, #5 May 85 pp. 923-929.
Catalogue of ATCC Cell lines & Hybridomas, 5.sup.th ed. 1985 pp. 3-5, American Type Culture Collectioin, Rockville, MD.
Chesebro, B., et al., "Failure of Human Immunodeficiency Virus Entry and Infection in CD4-Positive Human Brain and Skin Cells." J. Virology 64:215-221 (1990).
Maddon, et al., "The T4 Genes Encodes the AIDS Virus Receptor and is Expressed in the Immune System and the Brain" Cell 47:333-348 (1986).
Stanley, P. "Membrane Mutants of Animal Cells: Rapid Identification of Those with a Primary Defect in Glycosylation." Mol. & Cell Biol. 5:923-929 (1985.
Catalogue of ATCC Cell Lines & Hybridomas, 5th Ed., 1985, pp. 3-5. American Type Culture Collection, Rockville, MD.
Maddon et al. "The T4 Gene Encodes the AIDS Virus Receptor and Is Expressed in the Immune System and the Brain." Cell, vol. 47, Nov. 7, 1986, pp. 333-348. QH573.C38.
Stanley. "Membrane Mutants of Animal Cells: Rapid Identification of Those with a Primary Defect in Glycosylation." Molecular and Cellular Biology, vol. 5, No. 5, May 1985, pp. 923-929. QH506 .M6.
Catalogue of ATCC Cell Lines & Hybridomas, 5.sup.th edition, 1985, pp. 3-5, American Type Culture Collection, 12301 Parklawn Drive, Rockville, MD 20852-1776, Library of Congress Catalog Card No. 85-71973.
Chesebro Bruce
Wehrly Kathy
Nucker Christine M.
Stucker Jeffrey
The Unites States of America as represented by the Secretary of
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