Cell lines for use in the preparation of hybridoma cells

Details Cell lines for use in the preparation of hybridoma cells Cell lines for use in the preparation of hybridoma cells

1986-09-25

1992-06-30

Doll, John

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

4351722, 4352402, 43524026, 43524027, 435948, 435 702, C12P 2108, C12N 1500, C12N 500

Patent

active

051262533

ABSTRACT:
A novel cell line for use as a parent for hybridoma preparation is provided. This cell line is derived from tumor cells, in particular human tumor cells, other than those originating from bone marrow cells. A method for establishing this cell line is also provided. By fusing this cell line with cells producing useful physiologically active substances, such as B cells immunized with an antigen, a hybridoma capable of active growth can be prepared. This hybridoma can be cultivated for the production of useful physiologically active substances.

REFERENCES:
patent: 4195125 (1980-03-01), Wacker
patent: 4196265 (1980-04-01), Koprowski et al.
patent: 4434230 (1984-02-01), Ritts, Jr.
patent: 4693975 (1987-09-01), Kozbor et al.
Schumacher et al., "The Characterization of Four Monoclonal Antibodies Specific for Mouse IL-5 and Development of Mouse and Human IL-5 Enzyme-Linked Immunosorbent", Journal of Immunology, vol. 141, 1576-1581, No. 5, Sep. 1, 1988.
Harada et al., "Production of a Monoclonal Antibody Useful in the Molecular Characterization of Murine T--Cell-Replacing Factor/B-cell Growth Factor II", Proc. Natl. Acad. Sci. vol. 84, pp. 4581-4585, Jul. 1987.
Goding, Monoclonal Antibodies: Principles and Practice, Academic Press N.Y., (1983) p. 61.
Kahn et al., "Short-Lived Cytoplasmic Regulators of Gene Expression in Cell Cybrids", Nature 290 pp. 717-720 (1981).
Periman, "IgG Synthesis in Hybrid Cells from Antibody Producing Mouse Myeloma and an L Cell Substrain", Nature 228, pp. 1086-1087 (1970).
Imai et al., "Serological and Immunochemical Analysis of the Specificity of Xenoantiserum 8986 Elicited with Hybrids . . . ", Cancer Research 41 pp. 1026-1033 (1981).
Junker, "Regulation of Expression of Tyrosine Aminotransferase in Somatic Cell Hybrids between Rat Hepatoma Cells and Mouse Fibroblasts" Biochemical and Biophysical Research Communications 99(1), pp. 95-101 (1981).
Littlefield, "Selection of Hybrids from Matings of Fibroblasts in vitro and their Presumed Recombinants", Science 145, pp. 709-710 (1964).
Olsson et al., "Human Hybridomas Producing Monoclonal Antibodies of Predefined Antigenic Specificity", Proceedings of the National Academy of Sciences 77(9), pp. 5429-5431 (1980).
Curry et al., "Serological Detectable Human Melanoma-Associated Antigens are not Genetically Linked to HLA-A and B Antigens", Journal of Immunology 122(6), pp. 2630-2632 (1979).
Malaya Bhattacharya, et al., "Monoclonal Antibodies Recognizing . . . ", Cancer Research, 42, 1650-1654, May 1982.
Susumu Hosoi, et al., "Detection of Human Osteosarcoma-associated Antigen(s) . . . ", Cancer Research, 42, 654-659, Feb. 1982.
F. James Primus, et al., "Immunological Heterogeneity of Carcinoembryonic Antigen: . . . ", Cancer Research, 43, 686-692, Feb. 1983.
Eva Engvall, et al., "Monoclonal Antibodies in Analysis of Oncoplacental Protein . . . ", Cancer Research, 42, 2028-2033, May 1982.
Arthur E. Frankel, et al., "Monoclonal Antibodies to a Human Prostate Antigen", Cancer Research, 42, 3714-3718, Sep. 1982.
Yuichi Iwaki, et al., "Monoclonal Antibody against A.sub.1 Lewis d Antigen . . . ", Cancer Research, 42, 409-411, Feb. 1982.
G. Kohler and C. Milstein, "European Journal of Immunology", vol. 6, 511-519, Jul. 1976.
G. Kohler and C. Milstein, "Continuous Cultures of Fused Cells . . . ", Nature, vol. 256, 495-497, Aug. 7, 1975.
K. Imai et al., "Monoclonal Antibodies to Human Melanoma-Associated Antigens", Transplantation Proceedings, vol. XII, No. 3, 380-383, Sep. 1980.
Negoro et al.: "Several New Monoclonal Antibodies Directed . . . ", Cancer Research 42, 4259-4262, Oct. 1982.
Molecular Biology of the Gene, 4th Ed., James D. Watson et al., the Benjamin/Cummings Publishing Co., Inc., 1987, p. 844.
Nature, vol. 256, No. 5520, Aug. 28, 1975, pp. 751-753, Transformation of Human Cells in Culture by N-methyl-N'-nitro-N-nitrosoguanidine.

Affiliated with

Also associated with

Rating

Cell lines for use in the preparation of hybridoma cells does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cell lines for use in the preparation of hybridoma cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cell lines for use in the preparation of hybridoma cells will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1863309