Cell lines for the production of monoclonal antibodies to human

Chemistry: molecular biology and microbiology – Spore forming or isolating process

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4351722, 435 68, 935 95, 935103, 350387, C12N 500, C12N 1500, C12P 2100, C07K 1504

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047677104

ABSTRACT:
Cloned mouse hybridoma cell lines have been established which continuously produce antibodies that differentiate between the M and N forms of human glycophorin A. These antibodies have potential application as human blood group reagents, as markers for terminally differentiated erythroid cells and as immunofluorescent labels of somatically variant human erythrocytes.

REFERENCES:
patent: 4271145 (1981-06-01), Wanos
Edwards, P., Biochem Soc. Trans. vol. 9, pp. 334-335 (1980).
Anstee, D. et al, Eur. J. Immunol., vol. 12, pp. 228-232 (1982).
Boumsell, L. et al, J. Immunolog. Methods, vol. 38, pp. 225-229 (1980).
Noonan, K. et al., in Monoclonal Antibodies in Endocrine Res. (Eds. Fellows & Eisenbarth) pp. 41-52 (1981).
Springer, G. et al., Immunochemistry, vol. 14, pp. 497-502 (1977).
Anstee, D. in Monoclonal Antibodies in Clin. Med. (Eds. McMichael & Fabre) pp. 237-249 (1982).

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