Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1994-05-09
1996-09-10
Wax, Robert A.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
435 6, 4351721, 4351723, 935 77, C12N 508, C12N 1501, C12N 1554, C12N 1511
Patent
active
055545297
ABSTRACT:
Cell lines useful for analysis of human homologous interchromosomal recombination are described. The cell lines carry endogenous mutant alleles of a selectable gene and can regenerate a selectable phenotype through homologous genetic recombination but not by large deletion of nucleotides or by chromosome loss. Assays using the cell lines permit quantitative and qualitative analysis of recombination events which occur between human chromosomes in somatic cells in culture. The assay relies on normal genes in their normal chromosomal site. The assays can be used to test for environmental agents which induce homologous recombination in human cells.
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Benjamin Mark B.
Little John B.
President and Fellows of Harvard College
Prouty Rebecca
Wax Robert A.
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