Cell lines

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se

Reexamination Certificate

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C435S325000, C424S093200, C424S093700

Reexamination Certificate

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07419827

ABSTRACT:
Genomic instability in T-antigen expressing cells can be overcome by modifying the gene expressing T-antigen so that it lacks Bub1 binding. Stable cell lines can be produced by incorporation of the modified T-antigen gene, preferably together with the catalytic sub-unit of the telomerase construct.

REFERENCES:
patent: 5270191 (1993-12-01), McKay et al.
patent: 5580777 (1996-12-01), Bernard et al.
patent: 5690927 (1997-11-01), Major et al.
patent: 5753491 (1998-05-01), Major et al.
patent: 5770414 (1998-06-01), Gage et al.
patent: 5817773 (1998-10-01), Wilson et al.
patent: 5851832 (1998-12-01), Weiss et al.
patent: 5958767 (1999-09-01), Snyder et al.
patent: 6165715 (2000-12-01), Collins et al.
patent: 6197585 (2001-03-01), Stringer
patent: 6200806 (2001-03-01), Thomson
patent: 6399384 (2002-06-01), Jat
patent: 6465215 (2002-10-01), Price et al.
patent: 6528306 (2003-03-01), Snyder et al.
patent: 6569421 (2003-05-01), Hodges
patent: 2001/0001662 (2001-05-01), Sinden et al.
patent: 2002/0028510 (2002-03-01), Sanberg et al.
patent: 2002/0064873 (2002-05-01), Yang et al.
patent: 2002/0123143 (2002-09-01), Toma et al.
patent: 2002/0146821 (2002-10-01), Sanchez-Ramos et al.
patent: 2003/0108535 (2003-06-01), Hodges
patent: 2003/0143737 (2003-07-01), Morrison et al.
patent: 2003/0147873 (2003-08-01), Sinden et al.
patent: 2003/0203483 (2003-10-01), Seshi
patent: 2004/0185429 (2004-09-01), Kelleher-Andersson et al.
patent: 2005/0032213 (2005-02-01), Sinden et al.
patent: WO 89/03872 (1989-05-01), None
patent: WO 89/ 09816 (1989-10-01), None
patent: WO 91/09936 (1991-07-01), None
patent: WO 92/11355 (1992-07-01), None
patent: WO 93/01275 (1993-01-01), None
patent: WO 93/18137 (1993-09-01), None
patent: WO 96/15226 (1996-05-01), None
patent: WO 97/10329 (1997-03-01), None
patent: WO 98/07841 (1998-02-01), None
patent: WO 00/50568 (2000-08-01), None
patent: WO 01/21790 (2001-03-01), None
patent: WO 01/66698 (2001-09-01), None
patent: WO 01/66781 (2001-09-01), None
patent: WO 01/94541 (2001-12-01), None
patent: WO 03/00868 (2003-01-01), None
patent: WO 03/29432 (2003-10-01), None
Villa A, Navarro B, Martinez-Serrano A. Genetic perpetuation of in vitro expanded human neural stem cells: cellular properties and therapeutic potential. Brain Res Bull. Apr. 2002;57(6):789-94. Review.
U.S. Appl. No. 11/178,216, filed Jul. 8, 2005, Sinden et al.
U.S. Appl. No. 09/913,443, filed Aug. 14, 2001, Price.
Allay, J.A. et al. “LacZ and interieukin-3 expression in vivo after retroviral transduction of marrow-derived human osteogenic mesenchymal progenitors”Human Gene Therapy, 1997, 8:1417-1427.
Anderson, W.F. “Human gene therapy”Nature, 1998, 392:25-30.
Cepko, C.L. “Immortalization of neural cells via retrovirus-mediated oncogene transduction”Ann. Rev. Neurosci., 1989, 12:47-65.
Chen, J. et al. “Intravenous Administration of Human Umbilical Cord Blood Reduces Behavioral Deficits After Stroke in Rats”Stroke, 2001, 32:2682-2688.
Chopp, M. et al. “Adult bone marrow transplantation for treatment of stroke in adult mice”Society for Neuroscience, 1999, 25:1309, abstract No. 528.2 (abstract).
Cogle, C.R. et al. “Bone marrow transdifferentiation in brain after transplantation: a retrospective study”Lancet, 2004, 363(9419):1432-1437, abstract.
Coller, H.A. et al. “Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signalling, and adhesion”Proc. Natl. Acad. Sci, 2000, 973260-3265.
Crystal, R.G. “Transfer of genes to humans: early lessons and obstacles to success”Science, 1995, 270:404-410.
Daadi, M.M. and S. Weiss “Generation of tyrosine hydroxylase-producing neurons from precursors of the embryonic and adult forebrain”J. Neuroscience, 1999, 19(11):4484-4497.
Deonarain, M.P. “Ligand-targeted receptor-mediated vectors for gene delivery”Exp. Opin. Ther. Patents, 1998, 8(1):53-69.
Draper, J.S. et al. “Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells”Nature Biotech., 2004, 22(1):53-54.
Eglitis, M. and E. Mezey “Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice”Proc. Natl. Acad. Sci. USA, 1997, 94:4080-4085.
Flax, J.D. et al. “Engraftable human neural stem cells respond to developmental cues, replace neurons, and express foreign genes”Nature Biotech., 1998, 16(11):1033-1039.
Frederiksen, K. et al. “Immortalization of Precursor Cells from the Mammalian CNS”Neuron, 1988, 1:439-448.
Freed, C.R. et al. “Transplantation of embryonic dopamine neurons for severe Parkinson's Disease”New Engl. J Med., 2001, 344(10):710-719.
Goolsby, J. et al. “Hematopoietic progenitors express neural genes”PNAS, 2003, 100(25):14926-14931.
Gray, J.A. et al. “Prospects for the clinical application of neural transplantation with the use of conditionally immortalized neuroepithelial stem cells”Phil. Trans. R. Soc. Lond. B, 1999, 354:1407-1421.
Hao, H.N. et al. “Fetal human hematopoietic stem cells can differentiate sequentially into neural stem cells and then astrocytes in vitro”J. Hematother Stem Cell Res., 2003, 12(1):23-32.
Hess, D.C. et al. “Bone marrow as a source of endothelial cells and NeuN-expressing cells after stroke”Stroke, 2002, 33:1362-1368.
Hodges, H. et al. “Cognitive Deficits Induced by Global Cerebral Ischaemia: Prospects for Transplant Therapy”Pharm. Biochem. and Behavior, 1997, 56(4):763-780.
Inzunza, J. et al. “Comparative genomic hybridization and karyotyping of human embryonic stem cells reveals the occurrence of an isodicentric X chromosome after long-term cultivation”Mol Human Reprod., 2004, 10(6):461-466.
Jat, P. and Sharp, P. “Cell lines established by a temperature-sensitive simian virus 40 large-T-antigen gene are growth restricted at the nonpermissive temperature”Mol. Cell. Biology, 1989, 9(4):1672-1681.
Jat, P.S. “Direct derivation of conditionally immortal cell lines from anH-2Kb-tsA58 transgenic mouse”Proc. Natl. Acad Sci. USA, 1991, 88:5096-5100.
Kopen, G.C. et al. “Marrow stromal cells migrate throughout forebrain and cerebellium, and they differentiale into astrocytes after injection into neonatal mouse brains”Proc. Natl. Acad. Sci USA, Sep. 1999, 96:10711-10716.
Koshizuka, S. et al. “Transplanted hematopoietic stem cells from bone marrow differentiate into neural lineage cells and promote functional recovery after spinal cord injury in mice”J. Neuropath. Exp. Neurology, 2004, 63(1):64-72.
Littlewood, T.D. et al. “A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins”Nucl. Acids Res., 1995, 23:1686-1690.
Major, E.O. et al. “Establishment of a line of human fetal glial cells that supports JC virus multiplication”Proc. Natl. Acad. Sci. USA, 1985, 82:1257-1261.
McKay et al. “Mechanisms Regulating Cell Number and Type in the Mammalian Central Nervous System” cold Spring Harbor Symposia on Quantitative Biology, 1990, 55:291-301.
McKay et al. “Immortalized Stem Cells Form the Central Nervous System” C.R. Acad. Sci. Paris, Sciences De La Vie, 1993, 316:1452-1457.
Mezey, E. and K.J. Chandross “Bone marrow: a possible alternative source of cells in the adult nervous system”Euro. J. Pharmacology, 2000, 405:297-302.
Miller, N. and R. Vile “Targeted vectors for gene therapy”FASEB J., 1995, 9:190-199.
Nakatsuji, T. et al. “Establishment of cell lines from the yolk sac blood islands and paraaortic splanchnopleura of transgenic mouse embryos harboring an immortalizing gene”Cell Structure and Function, 1996, 21(6):624.
Netto, C.A. et al. “Foetal grafts from hippocampal regio superior alleviate ischaemie-induced behavioral deficits”Behavioural Brain Res., 1993, 58:107-112

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