Cell line producing human monoclonal antibody which binds to HTL

Details Cell line producing human monoclonal antibody which binds to HTL Cell line producing human monoclonal antibody which binds to HTL

1985-03-29

1988-02-02

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 7, 435 68, 43524027, 4351722, 436518, 436536, 436548, 436811, 436813, 935100, 935104, 935108, 935110, 424 86, 530387, 530389, 530826, 422 61, C12Q 170, G01N 3353, G01N 33577, A61K 3942

Patent

active

047228881

ABSTRACT:
The present invention is an immortalized B-cell line which produces a human monoclonal antibody IgG-Kk which specifically binds to the envelope antigen of human T-cell leukemia virus Type 1 (HTLV-I). This monoclonal antibody is useful as a diagnostic reagent by binding to the antigen specifically expressed on the surface of HTLV producing cells. Furthermore, this monoclonal antibody is useful as a therapeutic reagent, in combination with complement, for the lysis of HTLV-1 producing cells.

REFERENCES:
patent: 4588681 (1986-05-01), Sawada
Papas et al., Chemical Abstracts, 102 (1985) #198975.
Koyanagi et al., Med. Microbiol. Immunol., 173 (1984), 127-140.
Lee et al., Proc. Natl. Acad. Sci. U.S.A., 81 (1984), 3856-3860.

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