Cell line for the expression of an α2δ2 calcium...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S325000

Reexamination Certificate

active

07067262

ABSTRACT:
Described is a method for determining the binding ability of a compound to bind to an α2δ2 subunit of a calcium channel comprising: providing an α2δ2 subunit of a calcium channel, contacting the subunit with the compound, and determining the binding ability of the compound to bind to the subunit.

REFERENCES:
patent: 9639512 (1996-12-01), None
patent: 9908670 (1999-02-01), None
Gao et al., “Functional Properties of a New Voltage-dependent Calcium Channel alpha2delta Auxiliary Subunit Gene (CACNA2D2)”,The Journal of Biological Chemistry, vol. 275, No. 16, 2000, pp. 12237-12242.
Klugbauer et al., “Molecular Diversity of the Calcium Channel alpha2delta Subunit”,The Journal of Neuroscience, vol. 19, No. 2, 1999, pp. 684-691.
Gee et al., “The Novel Anticonvulsant Drug, Gabapentin (Neurontin), Binds to the alpha2delta Subunit of a Calcium Channel”,The Journal of Biological Chemistry, vol. 271, No. 10, 1996, pp. 5768-5776.
Suman-Chauhan et al., “Characterization of [3H]gahapentin binding to a novel site in rat brain: homogenate binding studies”,European Journal of Pharmacology—Molecular Pharmacology Section, vol. 244, 1993, pp. 293-301.
Su et al., “Human alpha2delta2 subunit of calcium channel: a novel gabapentin binding protein in rat”,Society for Neuroscience Abstracts, vol. 26, No. 2, 2000, Abstract No. 40.20.

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