Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...
Patent
1996-06-24
1999-02-02
Achutamurthy, Ponnathapura
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Animal cell, per se, expressing immunoglobulin, antibody, or...
435 721, 435 7021, 435236, 435260, 435325, 435328, 435339, 4242051, 4242161, 5303873, 5303883, A61K 39135, C07H 2104, C07K 14705, C12N 510
Patent
active
058664165
ABSTRACT:
A method of making a genetically-engineered cell line which is susceptible to infection by foot-and-mouth disease virus and allows the virus to replicate is disclosed. The method involves fusing the DNA encoding ICAM-1 with the DNA encoding an antibody specific for foot-and-mouth disease virus and expressing the resulting chimeric cell surface receptor protein. The chimeric cell surface receptor protein allows foot-and-mouth disease virus to bind, leading to subsequent infection and replication of foot-and-mouth disease virus. A genetically-engineered cell which expresses the chimeric cell surface receptor protein is also claimed.
REFERENCES:
patent: 5359046 (1994-10-01), Capon et al.
Mason et al. "Antibody-Complexed Foot-and-Mouth Disease Virus, But Not Poliovirus, Can Infect . . . " Virology 192, pp. 568-577, 1993.
Crowther et al. Epidemiol. Inf., 1993, vol. 111, pp. 391-406.
Baxt Barry
Berinstein Analia
Kang Angray S.
Mason Peter W.
Reider Elizabeth
Achutamurthy Ponnathapura
Bui Phuong T.
Fado John D.
Graeter Janelle S.
Silverstein M. Howard
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