Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Rodent cell – per se
Reexamination Certificate
2011-06-21
2011-06-21
Spector, Lorraine (Department: 1647)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Rodent cell, per se
C435S069100, C435S070100, C530S350000, C536S023500, C424S198100
Reexamination Certificate
active
07964399
ABSTRACT:
The present invention relates to the use of ligands for the FLK-1 receptor for the modulation of angiogenesis and vasculogenesis. The invention s based, in part, on the demonstration that Flk-1 tyrosine kinase receptor expression is associated with endothelial cells and the identification of vascular endothelial growth factor (VEGF) as the high affinity ligand of Flk-1. These results indicate a major role for Flk-1 in the signaling system during vasculogenesis and angiogenesis. Engineering of host cells that express Flk-1 and the uses of expressed Flk-1 to evaluate and screen for drugs and analogs of VEGF involved in Flk-1 modulation by either agonist or antagonist activities is described. The invention also relates to the use of FLK-1 ligands, including VEGF agonists and antagonists, in the treatment of disorders, including cancer, by modulating vasculogenesis and angiogenesis.
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Gazit Aviv
Levitzki Alex
Millauer Birgit
Risau Werner
Ullrich Axel
Foley & Lardner LLP
Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.v.
Spector Lorraine
Yissum Research Development Company of the Hebrew University of
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