Cell line and uses thereof

Details Cell line and uses thereof Cell line and uses thereof

2007-08-07

2007-08-07

Romeo, David S (Department: 1647)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S007210

Reexamination Certificate

active

10463123

ABSTRACT:
The subject invention relates to a novel cell line, referred to as T42402I3.4.2, and to uses of this cell line. For example, the cell line may be used in the production of recombinant melanin concentrating hormone (MCH) receptor protein and in the identification of antagonists, inverse agonists and agonists to the receptor.

REFERENCES:
Borowsky, B., et al., “Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist”,nature medicine, 8(8):825-830 (2002).
Bradley, R. L., et al., “Melanin-concentrating hormone activates signaling pathways in 3T3-L1 adipocytes”,EJP—Endocrinology and Metab.,283:E584-E592 (2002).
Burgaud, J-L., et al., “Melanin-Concentrating Hormone Binding Sites in Human SVK14 Keratinocytes”,Biochem. And Biophys. Res. Comm.,241:622-629 (1997).
Griffond, B. and Baker, B.I., “Cell and Molecular Cell Biology of Melanin-Concentrating Hormone”,Intn'l Rev. of Cytology, 213:233-277 (2002).
Hawes, B. E., et al., “The Melanin-Concentrating Hormone Receptor Couples to Multiple G Proteins to Activate Diverse Intracellular Signaling Pathways”,Endocrinology, 141(12):4524-4532 (2000).
Kokkotou, E., et al., “Characterization of [Phe13, Tyr19]-MCH analog binding activity to the MCH receptor”,Neuropeptides, 34(3&4):240-247 (2000).
Saito, Y., et al., “Endogenous Melanin-Concentrating Hormone Receptor SLC-1 in Human Melanoma SK-MEL-37 Cells”,Biochem.&Biophys. Res. Comm.,280:44-50 (2001).
Tadayyon, M., et al., “Expression of Melanin-Concentrating Hormone Receptors in Insulin-Producing Cells: MCH Stimulates Insulin Release in RINm5F and CRI-G1 Cell-Lines”,Biochem.&Biophys. Res. Comm.,275:709-712 (2000).
Takahashi, K., et al., “Expression of Melanin-Concentrating Hormone Receptor Messenger Ribonucleic Acid in Tumor Tissues of Pheochromocytoma, Ganglioneuroblastoma, and Neuroblastoma”,Journ. Of Clin. Endoc.&Metab.,86(1):369-374 (2001).
Takekawa, S., et al., “T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist”,Eur. Journ. Of Pharm.,438:129-135 (2002).
Rostomily, R.C., et al., “Expression of Neurogenic Basic Helix-Loop-Helix Genes in Primitive Neuroectodermal Tumors1”,Cancer Research, 57(16):3526-3531 (1997).
Schlumberger, S.E., et al., “Endogenous receptor for melanin-concentrating hormone in human neuroblastoma Kelly cells”,Biochem&Biophy Res Comm.,298:54-59 (2002).
Shimomura, Y., et al., “Isolation and Identification of Melanin-Concentrating Hormone as the Endogenous Ligand of the SLC-1 Receptor”,Biochem&Biophys Res Comm.,261:622-626 (1999).
Tumilowicz, J.J., “Definition of a Continuous Human Cell Line Derived from Neuroblastoma”,Cancer Research, 30(8):2110-2118 (1970).
“Melanin-concentrating hormone receptor 1”,Databsae UniProt, XP002316310 (1992).

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