Cell line and screening method with the use of the same

Details Cell line and screening method with the use of the same Cell line and screening method with the use of the same

2006-05-02

2006-05-02

Lankford, Jr., Leon B. (Department: 1651)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S366000, C424S900000

Reexamination Certificate

active

07037717

ABSTRACT:
An object of the present invention is to establish a clonal cell line of undifferentiated mesenchymal cells capable of differentiating into chondrocytes and adipocytes from a normal adult animal and to establish a screening method for cell differentiation-controlling materials. According to the present invention, cell lines capable of differentiating into chondrocytes and adipocytes, which are derived from normal adult animals; screening methods for cell differentiation-controlling materials using said cell lines; screening kits comprising said cell lines; cell differentiation-controlling materials obtained by said screening methods; and drugs containing said differentiation-controlling materials are provided.

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Pittenger et al., Oocytes and oogenesis. Osiris Therapeutics Inc.. 1772 (1996).
Aikawa et al., Establishment of bone morphogenetic protein 2 responsive chondrogenic cell line, Journal Of Bone And Mineral Research. 11(4)544-553 (1996).
Pietrangeli et al., Stromal cell lines which support lymphocyte growth: characterization, sensitivity to radiation and responsiveness to growth factors. Eur. J. Immunol., 18:863-872 (1988).

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