Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1998-11-25
2000-04-04
Russel, Jeffrey E.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424426, 424443, 424484, 424486, 424488, 435 29, 435178, 435179, 435180, 435181, 435182, 435370, 435372, 435398, 435399, 435400, 435402, 514 12, 514 21, 530812, 530815, 530816, A61K 3818, A61K 4730, C12Q 102, C12N 1108
Patent
active
060458186
ABSTRACT:
Disclosed are compositions with tethered growth effector molecules, and methods of using these compositions for growing cells and tissues. Growth effector molecules, including growth factors and extracellular matrix molecules, are flexibly tethered to a solid substrate. The compositions can be used either in vitro or in vivo to grow cells and tissues. By tethering the growth factors, they will not diffuse away from the desired location. By making the attachment flexible, the growth effector molecules can more naturally bind to cell surface receptors. A significant feature of these compositions and methods is that they enhance the biological response to the growth factors. The new method also offers other advantages over the traditional methods, in which growth factors are delivered in soluble form: (1) the growth factor is localized to a desired target cell population; (2) significantly less growth factor is needed to exert a biologic response. This method can be used as a means of enhancing the therapeutic use of growth factors in vivo and of creating surfaces which will enhance in vitro growth of difficult-to-grow cells such as liver cells.
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Cima Linda G.
Kuhl Philip R.
Merrill Edward W.
Massachusetts Institute of Technology
Russel Jeffrey E.
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