Cell growth regulator

Chemistry: analytical and immunological testing – Cancer

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436501, 435 723, 435 721, 435 724, 514 23, 514 54, G01N 3353, G01N 33574, A01N 4304

Patent

active

059623314

ABSTRACT:
A substance secreted or shed by muscle cells and white blood cells is disclosed. This novel substance is active in inhibiting proliferation of tumor cells and proliferation of stimulated lymphocytes. The substance does not inhibit proliferation of normal cells. This substance is used in accordance with the invention for treatment or prevention of cancer and the level of said substance in a body fluid or in a fluid conditioned by the growth therein of cells withdrawn from the individual, is used for the diagnosis of cancer or the level of risk of the individual of developing cancer.

REFERENCES:
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patent: 5242692 (1993-09-01), Djaldetti et al.
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Siegel, Israel, et al., Cytotoxic Effects of Free Fatty Acids on Ascites Tumor Cells, JNCI, vol. 78, No. 2, (Feb. 1987).
Parshley, Mary Stearns, Effect of Inhibitors from Adult Connective Tissue on Growth of a Series of Human Tumors in Vitro, Cancer Research, vol. 25.
Laug, Walter, E., Inhibition of Human Tumor Cell-Associated Fibrinolysis by Vascular Bovine Smooth Muscle Cells, JNCL. vol. 75, No. 2 (Aug. 1985).
Bohmer, Frank-D, et al., A Polypeptide Growth Inhibitor Isolated From Lactating Bovine Mammary Gland (MDGI) is a Lipid-Carrying Protein, Journal of Cellular Biochemistry 38:199-204 (1988).
S.A. Hoffman, The Influence of Exercise on the Growth of Transplated Rat Tumors, vol. 22, Jun. 1962, pp. 597-599.
Vickie E. Baracos, Exercise Inhibits Progressive Growth of the Morris Hepatoma 7777 in Male and Female Rats, Aug. 31, 1988, pp. 864-870.
Albert Szent-Gyorigyi, Cancer Therapy: A Possible New Approach, Science, vol. 140, May 1963, pp. 1391-1392.
T. Namba, Inhibition of Ehrlich Ascites Tumour Cells by Skeletal Muscle Extracts, Jan. 8, 1968, pp. 294-301.

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