Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Patent
1986-10-31
1989-08-22
Rosen, Sam
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
424 71, 424 9, 435 32, 4352402, 436 63, 436172, C12Q 102, C12Q 118
Patent
active
048595845
ABSTRACT:
Methods for determining growth rate of cells growing in vivo and in vitro. Cells are labelled with cyanine dyes and changes in plasma membrane cyanine dye levels are used to determine growth rate. Cell growth rate determinations are utilized to monitor transplanted bone marrow cell engraftment and post-surgical corneal epitheal cell growth. The invented methods also are used to determine tumor cell sensitivity to cancer therapeutic agents, yeast sensitivity to antifungal agents, and bacteria sensitivity to antibacterial agents.
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Horan Paul K.
Jensen Bruce D.
Slezak Sue E.
Lourie Alan D.
Rosen Sam
Saunders D. A.
SmithKline Beckman Corporation
Suter Stuart R.
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