Cell growth inhibitory macrocyclic lactones denominated Combreta

Details Cell growth inhibitory macrocyclic lactones denominated Combreta Cell growth inhibitory macrocyclic lactones denominated Combreta

1989-04-26

1990-07-10

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514908, 549266, 549267, 549270, A61K 31365, C07B32100

Patent

active

049407260

ABSTRACT:
The isolation and elucidation of novel caffrane macrocyclic lactones denominated "Combretastatin D-1" and "Combretastatin D-2", each of which was found to possess unexpected cell growth inhibitory properties. The lactones have the structural formula: ##STR1## wherein: ##STR2##

REFERENCES:
patent: 4708962 (1987-11-01), Higa et al.
G. Pettit, et al., J. Am. Chem. Soc., "Isolation and Structure of Combretastatin D-1", 110(25), pp. 3539-3540 (1988).

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