Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1985-04-15
1987-06-09
Phillips, Delbert R.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C07K 1500
Patent
active
046721070
ABSTRACT:
A cell growth inhibitor consisting essentially of a peptide substantially free of cytotoxins and containing an amino acid sequence of Phe-Cys-Arg-Phe-Leu-Leu-Cys-Pro-Ser-Arg-Thr-Ser-Asp. The peptide may be obtained by fractionation of venom from proteroglyphodont snakes. One cytostatically active fraction contains a peptide with a molecular weight of 3200-3500 daltons, 27-29 amino acid groups, and a blocked amino terminus. Another fraction contains an oligomer or precursor of the lower molecular weight peptide. Also disclosed is a method of inhibiting the growth of cells by introducing the cell growth inhibitor to the cells to be inhibited in an effective amount.
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Inbex, Inc.
Phillips Delbert R.
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