Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Reexamination Certificate
2006-04-18
2006-04-18
McKelvey, Terry (Department: 1636)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
C435S004000, C435S325000, C435S449000, C435S346000, C536S026600
Reexamination Certificate
active
07029868
ABSTRACT:
Methods of identifying inhibitors of the fusion of two types of cells, particularly when fusion is mediated by the interaction of a viral protein and such cellular proteins as CD4 and chemokine receptors, are disclosed. The methods are suitable for identifying substances that are useful for the treatment and prevention of viral diseases. Particularly preferred methods are useful for the identification of inhibitors of HIV-1 infection.
REFERENCES:
patent: 5741657 (1998-04-01), Tsien et al.
patent: 5981200 (1999-11-01), Tsien et al.
patent: 6031094 (2000-02-01), Tsien et al.
Cohen et al. Methodologies in the study of cell-cell fusion. Methods. vol. 16, No. 2, pp. 215-226, Oct. 1998.
Pecheur et al. Peptides and membrane fusion: towards and understanding of the molecular mechanism of protein-induced fusion. Journal of Membrane Biology. vol. 167, pp. 1-17, Jan. 1999.
Dutch et al. Membrane fusion promoted by increasing surface densities of the paramyxovirus F and HN proteins. J Virol. vol. 72, No. 10, pp. 7745-7753, Oct. 1998.
Horvath et al. Biological activity of paramyxovirus fusion proteins: factors influencing formation of syncytia. J Virol. vol. 66, No. 7, pp. 4564-4569, Jul. 1992.
Gravel et al. Interacting domains of the HN and F proteins of newcastle disease virus.□□J Virol. vol. 77, No. 20, pp. 11040-11049, Oct. 2003.
Feng et al., “HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor”, Science, vol. 272, pp. 872-877 (May 1996).
Cocchi, et al., “Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppresive Factors Produced by CD8+ T Cells”, Science, vol. 270, pp. 1811-1815 (Dec. 1995).
Berger, “HIV entry and tropism: the chemokine receptor connection”, AIDS, vol. 11, Suppl. A, pp. S3-S16 (1997).
Rucker et al., “Utilization of Chemokine Receptors, Orphan Receptors, and Herpesvirus-Encoded Receptors by Diverse Human and Simian Immunodeficiency Viruses”, Journal of Virology, vol. 71, No. 12, pp. 8999-9007 (1997).
Wyatt and Sodroski, “The HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and Immunogens”, Science, vol. 280, pp. 1884-1888 (Jun. 1998).
Zhang et al., “HIV-1 subtype and second-receptor use”, Nature, vol. 383, p. 768 (Oct. 1996).
Connor et al., “Change in Coreceptor Use Correlates with Disease Progression in HIV-1-Infected Individuals”, J. Exp. Med., vol. 185, No. 4, pp. 621-628 (Feb. 17, 1997).
Bjorndal et al., “Coreceptor Usage of Primary Human Immunodeficiency Virus Type 1 Isolates Varies According to Biological Phenotype”, Journal of Virology, vol. 71, No. 10, pp. 7478-7487 (1997).
Scarlatti et al., “In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppresion”, Nature Medicine, vol. 3, No. 11, pp. 1259-1265 (Nov. 1997).
Bazan et al., “Patterns of CCR5, CXCR4, and CCR3 Usage by Envelope Glycoproteins from Human Immunodeficiency Virus Type 1 Primary Isolates”, Journal of Virology, vol. 72, No. 5, pp. 4485-4491 (1998).
Nussbaum et al., “Fusogenic Mechanisms of Enveloped-Virus Glycoproteins Analyzed ay a Novel Recombinant Vaccinia Virus-Based Assay Quantitating Cell Fusion-Dependent Reproter Gene Activation”, Journal of Virology, vol. 68, No. 9, pp. 5411-5422 (Sep. 1994).
Weiss et al., “Studies of HIV-1 envelope glycoprotein-mediated fusion using a simple fluorescence assay”, AIDS, vol. 10, No. 3, pp. 241-246 (1996).
Litwin et al., Human Immunodeficiency Virus Type 1 Membrane Fusion Mediated by a Laboratory-Adapted Strain and a Primary Isolate Analyzed by Resonance Energy Transfer, Journal of Virology, vol. 70, pp. 6437-6441 (1996).
Zlokarnik et al., “Quantitation of Transcription and Clonal Selection of Single Living Cells with β-Lactamase as Reporter”, Science, vol. 279, pp. 84-88 (Jan. 1998).
Clegg, “Fluorescence resonance energy transfer”, Current Opinion in Biotechnology, vol. 6, pp. 103-110 (1995).
Berger et al., “Chemokine Receptors as HIV-1 Coreceptors: Roles in Viral Entry, Tropism, and Disease”, Annu. Rev. Immunol., vol. 17, pp. 657-700 (1999).
Owman et al., “The leukotriene B4 receptor functions as a novel type of coreceptor mediating entry of primary HIV-1 isolates into CD4-positive cells”, Proc. Natl. Acad. Sci. USA, vol. 95, pp. 9530-9534 (Aug.1998).
Samson et al., “ChemR23, a putative chemoattractant receptor , is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains”, Eur. J. Immunol., vol. 28, pp. 1689-1700 (1998).
Albrecht et al., “Dual-Action Cephalosporins: Cephalosporin 3′-Quaternary Ammonium Quinolones”, J. Med. Chem., vol. 34, pp. 669-675 (1991).
Cammack, “Human immunodeficiency virus type 1 entry and chemokine receptors: a new therapeutic target”, Antiviral Chemistry & Chemotherapy, vol. 10, pp. 53-62 (1999).
McManus and Doms, “Fusion Mediated by the HIV-1 Envelope Protein”, Subcellular Biochemistry, vol. 34: Fusion of Biological Membranes and Related Problems, pp. 457-481, New York (2000).
Sittampalam et al., “High-throughput screening: advances in assay technologies”, Current Opinion in Chemical Biology, vol. 1, pp. 384-391 (1997).
Szollosi et al., “Application of Fluorescence Resonance Energy Transfer in the Clinical Laboratory: Routine and Research”, Cytometry (Communications in Clinical Cyometry), vol. 34, pp. 159-179 (1998).
De Silva, et al., “Emerging fluorescence sensing technologies: From photophysical principles to cellular applications,” Proc. Natl. Acad. Sci. USA, vol. 96, pp. 8336-8337 (Jul. 1999).
Mathis, “Probing Molecular Interactions with Homogeneous Techniques Based on Rare Earth Cryptates and Fluorescence Energy Transfer”, Clinical Chemistry, vol. 41, No, 9, pp. 1391-1397 (1995).
Heery et al., “A signature motif in transcriptional co-activators mediates binding to nuclear receptors”, Nature, vol. 387, pp. 733-736 (Jun. 1997).
Montminy, “Something new to hang your HAT on”, Nature, vol. 387, pp. 654-655 (Jun. 1997).
Torchia et al., “The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function”, Nature, vol. 387, pp. 677-684 (Jun. 1997).
Benincasa Diana
Cascieri Margaret A.
Mitnaul Lyndon J.
Shiao Lin-Lin
Sullivan Kathleen A.
Dunston Jennifer
Giesser Joanne M.
McKelvey Terry
Merck & Co. , Inc.
Switzer Joan E.
LandOfFree
Cell fusion assays using fluorescence resonance energy transfer does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cell fusion assays using fluorescence resonance energy transfer, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cell fusion assays using fluorescence resonance energy transfer will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3591447