Cell-free synthesis of deacetoxycephalosporin C

Details Cell-free synthesis of deacetoxycephalosporin C Cell-free synthesis of deacetoxycephalosporin C

1981-01-07

1981-12-22

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound having a 1-thia-5-aza-bicyclo

435926, C12P 3500

Patent

active

043071929

ABSTRACT:
A cell-free process for converting isopenicillin N, .delta.-(L-.alpha.-aminoadipyl)-L-cysteinyl-D-valine (hereinafter "LLD") and 6-substituted derivatives thereof to deacetoxycephalosporin C (DACPC) by the following reaction sequence: ##STR1## is disclosed. In addition to the starting material, the reaction system includes ATP and a fresh extract of Cephalosporium acremonium prepared and used in a manner to preserve the racemase agent or agents necessary for conversion of the isopenicillin N to penicillin N, a necessary intermediate step in the process.

REFERENCES:
patent: 3847742 (1974-11-01), Higgens et al.
patent: 3979260 (1976-09-01), Nakao et al.
patent: 4178210 (1979-12-01), Demain et al.

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