Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-04-11
1997-03-04
Nucker, Christine M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 721, 436503, 436813, C12Q 168
Patent
active
056078331
ABSTRACT:
This invention pertains to a method of assessing the ability of a compound to block or activate cell proliferation by assessing its effect on a cellular signal transduction pathway whose activation results in cell proliferation. In the present method, a cell-free system is used to assess the ability of a compound to block or activate a signal transduction pathway which is activated by binding of a growth factor to a cell surface receptor with intrinsic tyrosine kinase activity and whose activation results in proliferation of the cells to which growth factor has bound. Cellular signal transduction involves multiple pathways, each consisting of one or more steps emanating from a specific protein bound to a single receptor which is specific for that protein and located on the cell surface or within the cell.
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Gilman Michael Z.
Sadowski Henry B.
Cold Spring Harbor Laboratory
Nucker Christine M.
Wortman Donna C.
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