Cell fragility testing method and appliance therefor

Details Cell fragility testing method and appliance therefor Cell fragility testing method and appliance therefor

1978-02-22

1979-12-11

Marantz, Sidney

Chemistry: physical processes

Physical processes

Crystallization

233 25, 422 72, 424 12, G01N 3316

Patent

active

041781520

ABSTRACT:
A method of and an appliance for use in testing the osmotic fragility of blood cells by the use of the CPC method involving a coil column containing an aqueous solution of a salt mixed with one or both of a viscosity modifier and a hemolysis promotor. This coil column, after the blood to be tested has been injected, is centrifuged while undergoing a planetary motion to cause the blood cells to undergo hemolysis. After this hemolysis, a hematological pattern is developed in the coil column, the position of the coil column at which such hematological pattern has been developed being indicative of the osmotic fragility of the subject blood.

REFERENCES:
K. Takagi et al., Clinical Blood, 17(11), 1153-1160 (1976).
K. Kitazima et al., J. Lab. Clin. Med., 85(5), 855-865 (1975).
S. Ogita et al., J. Jap. Soc. Obstetrics & Gynecology, 27(10), 1099-1102 (1975).
Y. Ito et al., Nature, 212(5066), 985-987 (Dec. 3, 1966).
"Clinical Diagnosis", I. Davidson et al., eds., 14th Edition, 149-155, W. B. Saunders Co., Phila., 1969.

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