Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Animal or plant cell
Patent
1997-08-05
1999-11-09
Naff, David M.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Animal or plant cell
424423, 435 701, 435 703, 435 711, 435 712, 435177, 435180, 435182, 435382, 435395, 435401, 435402, 435403, A01N 6300, C12P 2104, C12N 1104, C12N 500
Patent
active
059808896
ABSTRACT:
Cell encapsulating devices capable of maintaining large numbers of viable cells are provided containing an inert, substantially cell-free core that displaces cells, a permeable membrane and a zone for maintaining cells. The permeable membrane surrounds the core such that the zone of cells is bounded by the core and the permeable membrane. The cell zone may contain a support means for cell attachment and the core may have an outer boundary containing a material that promotes cell adhesion. Preferably, the cell zone has a thickness such that at least about 10% of the cells, more preferably at least about 50% or 80%, in a cell layer located closest to the outer boundary of the core remain viable. The thickness is preferably less than 500 microns such as 25 to 250 microns or 50 to 100 microns. The devices are suitable for implantation into an individual in need of treatment and are capable of supplying therapeutic substances to such individuals.
REFERENCES:
patent: 3993072 (1976-11-01), Zaffaroni
patent: 4298002 (1981-11-01), Ronel et al.
patent: 4323457 (1982-04-01), Sen et al.
patent: 4353888 (1982-10-01), Sefton
patent: 4378016 (1983-03-01), Loeb
patent: 4391909 (1983-07-01), Lim
patent: 4409331 (1983-10-01), Lim
patent: 4420589 (1983-12-01), Stoy
patent: 4495288 (1985-01-01), Jarvis, Jr. et al.
patent: 4505266 (1985-03-01), Yanas et al.
patent: 4631188 (1986-12-01), Stoy et al.
patent: 4663286 (1987-05-01), Tsang et al.
patent: 4673566 (1987-06-01), Goosen et al.
patent: 4686098 (1987-08-01), Kopchick et al.
patent: 4722898 (1988-02-01), Errede et al.
patent: 4743545 (1988-05-01), Torobin
patent: 4789550 (1988-12-01), Hommel et al.
patent: 4803168 (1989-02-01), Jarvis, Jr.
patent: 4806355 (1989-02-01), Goosen et al.
patent: 4892538 (1990-01-01), Aebischer et al.
patent: 4902295 (1990-02-01), Walthall et al.
patent: 4911717 (1990-03-01), Gaskill, III
patent: 4941812 (1990-07-01), Samelson
patent: 4942129 (1990-07-01), Goosen et al.
patent: 4969705 (1990-11-01), Stoy et al.
patent: 4997443 (1991-03-01), Walthall et al.
patent: 5002661 (1991-03-01), Chick et al.
patent: 5011486 (1991-04-01), Aebischer et al.
patent: 5017490 (1991-05-01), Taiariol et al.
patent: 5030225 (1991-07-01), Aebischer et al.
patent: 5081035 (1992-01-01), Halberstadt et al.
patent: 5084350 (1992-01-01), Chang et al.
patent: 5100392 (1992-03-01), Orth et al.
patent: 5106627 (1992-04-01), Aebischer et al.
patent: 5109866 (1992-05-01), Guegan et al.
patent: 5116493 (1992-05-01), Chick et al.
patent: 5116494 (1992-05-01), Chick et al.
patent: 5116753 (1992-05-01), Beattie et al.
patent: 5158881 (1992-10-01), Aebischer et al.
patent: 5182111 (1993-01-01), Aebischer et al.
patent: 5284761 (1994-02-01), Aebischer et al.
patent: 5314471 (1994-05-01), Brauker et al.
patent: 5344454 (1994-09-01), Clarke et al.
patent: 5418154 (1995-05-01), Aebischer et al.
patent: 5453278 (1995-09-01), Chan et al.
Calafiore, et al., "Vascular Graft of Microencapsulated Human Pancreatic Islets in Non-immunosuppressed Diabetic Recipients: Preliminary Results", Diab. Nutr. Metab., 4:45-48, Feb. 1991.
Hughes, et al., "Engineering of Glucose-stimulated Insulin Secretion and Biosynthesis in Non-islet Cells", Proc. Natl. Acad. Sci., U.S.A., 89:688-692, Jan. 1992.
Lienhard, et al., "How Cells Absorb Glucose", Scientific American, Jan. 1992, pp. 34-39.
Monaco, et al., "Transplantation of Islet Allografts and Xenografts in Totally Pancreatectomized Diabetic Dogs Using the Hybrid Artificial Pancreas", Ann. Surg., 214:339-362, Sep. 1991.
Reach, "Artificial and Bioartificial Replacement of the Endocrine Pancreas", Artificial Organs, 16:61-70, 1992.
Schrezenmeir, et al., "The Role of Oxygen Supply in Islet Transplantation", Transplantation Proceedings, 24:2925-2929, Dec. 1992.
Selam, et al., "Devices for Insulin Administration", Diabetes Care, 13:955-979, Sep. 1990.
Dinsmoor, "Miracle Membranes", Countdown, 13:34-39, 1992.
Sullivan, et al., "Biohybrid Artificial Pancreas: Long-Term Implantation Studies in Diabetic, Pancreatectomized Dogs", Science, 252:718-721, May 1991.
Colton, et al., "Bioengineering in Development of the Hybrid Artificial Pancreas", J. Biomech. Eng., 113:152-170, 1991.
Lacy, et al. "Maintenance of Normoglycemia in Diabetic Mice by Subcutaneous Xenografts of Encapsulated Islets", Science, 254:1782-1784, 1991.
Dionne, et al., "Effect of Hypoxia on Insulin Secretion by Isolated Rat and Canine Islets of Langerhans", Diabetes, 42:12-20, 1993.
Jauregui, et al., "Hybrid Artificial Liver", in Biocompatible Polymers, Metals and Other Composites, Szycher, M. (ed)., Lancaster, PA Technomic Pub., 1983, 907-928.
Aebischer, et al. "Transplantation of Polymer Encapsulated Neurotransmitter Secreting Cells: Effect of the Encapsulation Technique", J. Biomech. Eng., 113:178-183, 1991.
Guenard, et al. "Syngeneic Schwann Cells Derived From Adult Nerves Seeded in Semipermeable Guidance Channels Enhance Peripheral Nerve Regeneration", J. Neuroscience, 12:3310-3320, 1992.
Ohgawara, et al. "Successful Implantation of Cultured Allo-And Xenograft Islets With The Use of A Diffusion Chamber", Life Support Systems, 3 Suppl 1: (645-8), 1985.
Theodorou, et al. "An Assessment of Diffusion Chambers For Use in Pancreatc Islet Cell Transplantation", Transplantation, 27:350-353; 1978.
Tresco, et al. "Polymer Encapsulated Neurotransmitter Secreting Cells: Potential Treatment for Parkinson's Disease", ASA10 J., 38:17-23, 1992.
Guenard, et al., "Influence of Surface Texture of Polymeric Sheets on Peripheral Nerve Regeneration In a Two-Compartment Guidance System", Biomaterials, 12:259-263, 1991.
Jaeger, et al., "Repair of the Blood-Brain Barrier Following Implantation of Polymer Capsules" Brain Research, 551:163-170, 1991.
Jaeger, et al., Polymer Encapsulated Dopaminergic Cell Lines As Alternative Neural Grafts, Prog. Brain Res., 82:41-46, 1990.
Scharp, et al. "Islet Immuno-isolation: The Use of Hybrid Artificial Organs to Prevent Islet Tissue Rejection", World J. Surg., 8:221-229, 1984.
Altman et al., "Long-Term Plasma Glucose Normalization in Experimental Diabetic Rats With Macroencapsulated Implants of Benign Human Insulinomas", Diabetes, 35:625-633 (1986).
Tze, et. al., Nature, vol. 264, Dec. 1976, pp. 466-467.
Sun, et. al., Diabetes, vol. 26, No. 12, Dec. 1977, pp. 1136-1139.
Butler Mark D.
Mish Stanley L.
Gore Hybrid Technologies, Inc.
Naff David M.
Sonnenfeld Kenneth H.
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