Cell division inhibitor and a production method thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C514S252010, C514S255030, C544S357000, C544S368000, C544S370000, C544S385000

Reexamination Certificate

active

06972289

ABSTRACT:
The present invention relates to a cell division inhibitor comprising various dehydrodiketopiperazines such as dehydrophenylahistin, or analogs thereof as an active ingredient, and a dehydrogenase and a method for producing the same inhibitor.

REFERENCES:
patent: WO96/20190 (1996-07-01), None
Akerlund et al., “Diketopiperazine-Based Polymers from Common Amino Acids”, ouurnal of Applied Polymer Science (2000), 78 (12), 2213-2218.
Saito et al, Synthesis of novel octahydro-1, 5-imino-3-benzazocin-4, 7, 10-trione derivatives having a methyl group at the C-2 position as ABC ring models of saframycins. Chemical & Pharmaceutical Bulletin (1997), 45(7), 1120-1129.
Fukushima et al., “Biological Activities of Albonoursin,”J. Antibiotics,26: 175 (1973).
Kanoh et al., “(-)-Phenylahistin: A New Mammalian Cell Cycle Inhibitor Produced byAspergillus USTUS,” Bioorganic&Medicinal Chemistry Letters,7: 2847-2852 (1997).
Kanoh et al., “Synthesis and Biological Activities of Phenylahistin Derivatives,”Bioorganic&Medicinal Chemistry, 7: 1451-1457 (1999).
Kanoh et al., “Antitumor Activity of Phenylahistin in Vitro and in Vivo,”Bioscience Biotechnology Biochemistry,63: 1130-1133 (1999).
Kanoh et al., “(-)-Phenylahistin Arrests Cells in Mitosis by Inhibiting Tubulin Polymerization,”The Journal of Antibiotics,52: 134-141 (1999).
Kanzaki et al., “Effective Production of Dehydro Cyclic Dipeptide Albonoursin Exhibiting Pronuclear Fusion Inhibitory Activity,”The Journal of Antibiotics,52: 1017-1022 (1999).
Kanzaki et al.,A Summary of the Symposium of the Society for Actinomycetes Japan,p. 42 (1999).
Kobayashi et al.,A Summary of the Symposium on the Chemistry of Natural Products,p. 51 (1989).
Kopple et al., “A Convenient Synthesis of 2,5-Piperazinediones1a,”The Journal of Organic Chemistry,33: 862-864 (1967).
Nitecki et al., “A Simple Route to Sterically Pure Diketopiperazines1,”The Journal of Organic Chemistry,33: 864-866 (1968).
Sezaki and Shoten, “Drug Delivery Systems”,Drug Development,13: 116, Table 2. 29, (Jul. 1989).
Amendment and Response to Written Opinion submitted in International Application No. PCT/US03/024232 on Jan. 20, 2005.

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