Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-06-01
1998-12-15
Cook, Rebecca
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31415
Patent
active
058497773
ABSTRACT:
The invention provides cell modulators comprising certain biologically-active enantiomers of mevalonate and mevalonolactone derivatives. The compounds are broadly clinically useful, particularly in cancer management and treatment or immunological diseases or disorders.
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Kesseler et al, "Synthesis and Biological Activity of New HMG-CoA Reductase Inhibitors. 1. Lactones of Pyridine-and Pyrimidine-Substituted 3,5-Dihydroxy-6-heptenoic (-heptanoic) Acids", J. Med. Chem. 33:52-60 (1990).
Mann, "Membrane Oligosaccharides: Structure and Function during Differentiation", International Review of Cytology 112:67-96 (1988).
Mann Paul L.
Scallen Terence J.
Cook Rebecca
University of New Mexico
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