Cell differentiation inducer

Details Cell differentiation inducer Cell differentiation inducer

2008-01-08

2008-01-08

Andres, Janet L. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

Reexamination Certificate

active

10753365

ABSTRACT:
The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune diseases, dermatologic diseases and parasitism. In particular, they are highly effective as an anticancer drug, specifically to a hematologic malignancy and a solid carcinoma.

REFERENCES:
patent: 5541178 (1996-07-01), Betts et al.
patent: 0490667 (1992-06-01), None
patent: 6-179622 (1994-06-01), None
patent: 6-192073 (1994-07-01), None
patent: 6-256181 (1994-09-01), None
patent: 6-305955 (1994-11-01), None
patent: 6-316520 (1994-11-01), None
patent: 7-206765 (1995-08-01), None
patent: 7-258100 (1995-10-01), None
patent: WO96/21648 (1996-07-01), None
patent: WO97/24328 (1997-10-01), None
Hcaplus 1996:518048.
Hcaplus 1994:426079.
Hcaplus 144:80423.
H. Meng-er et al, “Use of All-Trans Retinoic Acid in the Treatment of acute prymyelocytic Leukemia”,Blood, vol. 72, No. 2, Aug. 1988, pp. 567-572.
S. Castaigne et al, “All-Trans Retinoic Acid as a Differentiation Therapy for Acute Promyelocytic Leukemia. I. Clinical Results”,Blood, vol. 76, No. 9, Nov. 1990, pp. 1704-1709.
R. Warrell, Jr., “Differentiation Therapy of Acute Promyelocytic Leukemia With Tretinoin(All-Trans-Retinoic Acid”,The New England Journal of Medicine, vol. 324, No. 20, May 1991, pp. 1385-1393.
I. Olsson et al, “Introduction of Differentiation of the Human Histiocytic Lymphoma Cell Line U-937 b 1α, 25-Dihydroxycholecalciferol”,Cancer Research, vol. 43, Dec. 1983, pp. 5862-5867.
M. Clark et al, “Validation of the General Purpose Tripos 5.2 Force Field”,Journal of Computational Chemistry, vol. 10, No. 8, 1989, pp. 982-1012.
Chemical Abstracts, vol. 63, No. 13, Dec. 20, 1995, Columbus, OH, US; Abstract No. 18311g, B.S. Portnaya et al; XP002051609 & Zhurnal Nauchnoi I Prikladnoi Fotografii I Kinematografii, vol. 10, No. 4, 1965 Moscow ISSN 0044-4561, pp. 278-287.
Chemical Abstracts, vol. 119, No. 25, Dec. 20, 1993, Columbus, OH, US; Abstract No. 270986n, J. Nowakowski: XP002051610 & PL 157 443 B (Uniwersytet Mikolaja Kopernika).
Y.V. Mitin et al, “Rearrangement of ortho-O-aminoacyl, N-acylaminophenol”, Tetrahedron Letters, No. 12, 1979, Oxford GB, pp. 1081-1084, XP002051608.
Marston et al., “On the active principles of the Euphorbiacease. VI, Isolation and biological activities of seven milliamines from Euphorbia milii”, CA Reference 100:64966k, p. 327, vol. 100, 1984.
Kuenzle et al, CA 70: 106484w, Seven membered heterocyclics, XII, Bibenz-[b,f]-1,4-oxazepin-11(10H)-ones and dibenz [b,e]-1,4-oxazipin- 11(5H)-ones, p. 343, 1969.

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