Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Patent
1984-07-10
1986-11-25
Kight, John
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
530350, 530380, 530387, 530402, 530403, 530808, 530810, 424 85, 424 88, 435181, 436547, C07K 700, A61K 3702
Patent
active
046250140
ABSTRACT:
A photo-cleavable compound for delivery and release of a biologically active substance to selected target cells; the compound includes a binding partner for a specific cell-surface receptor of those target cells, the biologically active substance to be delivered, and a photo-cleavable bridge between the binding partner and the biologically active substance. When the compound is exposed to a heterogeneous population of target and non-target cells, it binds selectively to the receptors on the surface of the target cells. Exposing the compound to light of selected wave length cleaves it, yielding the active substance.
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Blattler Walter A.
Lambert John M.
Senter Peter D.
Dana-Farber Cancer Institute Inc.
Draper Garnette D.
Kight John
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