Cell death regulators

Details Cell death regulators Cell death regulators

1993-08-26

1997-11-25

Wax, Robert A.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4352402, 4352523, 43525411, 4353201, 4351723, 536 235, 536 2431, C12N 1512, C12N 1563, C12N 510, C12N 100

Patent

active

056911793

ABSTRACT:
A Bcl-2 associated protein (Bax) and uses thereof.

REFERENCES:
Silverman, G.A., et al., "Meiotic recombination between yeast artificial chromosomes yields a single clone containing the entire BCL2 protooncogene," Proc. Natl. Acad. Sci. USA, (1990) 87, 9913-9917.
Young, R.L., et al., "A Negative Regulatory Element in the bcl-2 5'-Untranslated Region Inhibits Expression from an Upstream Promoter," Mol. & Cell Biol., (1993) 13:6, 3686-3697.
Nunez, G., et al., "Deregulated Bcl-2 Gene Expression Selectively Prolongs Survival of Growth Factor-Deprived Hemopoietic Cell Lines," J. Immun., (1990) 144:9, 3602-3610.
Sentman, C.L., "blc-2 Inhibits Multiple Forms of Apoptosis but Not Negative Selection in Thymocytes," Cell, (1991) 67, 879-888.
Nunez, G., et al., "Bcl-2 maintains B cell memory," Nature, (1991) 353, 71-73.
McDonnell, T.J., et al., "Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)," Nature, (1991) 349, 254-256.
McDonnell, T.J., et al., "Deregulated Bcl-2-Immunoglobulin Transgene Expands a Resting but Responsive Immunoglobulin M and D-Expressing B-Cell Population," Mol. & Cell Biol., (1990) 10:5, 1901-1907.
McDonnell, T.J., et al., "bcl-2-Immunoglobulin Transgenic Mice Demonstrate Extended B Cell Survival and Follicular Lymphoproliferation," Cell, (1989) 57, 79-88.
Zutter, M., et al., "Immunolocalization of the Bcl-2 Protein Within Hematopoietic Neoplasms," Blood, (1991) 78:4, 1062-1068.
Hockenbery, D.M., "BCL2 Protein is topographically restricted in tissues characterized by apoptotic cell death," Proc. Natl. Acad. Sci. USA, (1991) 88, 6961-6965.
Hockenbery, D.M., "Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death," Nature, (1990) 348, 334-336.
Korsmeyer, S.J., "Bcl-2 Initiates a New Category of Oncogenes: Regulators of Cell Death," Blood, (1992) 80:4, 879-886.
Nakayama, K., "Disappearance of the Lymphoid System in Bcl-2 Homozygous Mutant Chimeric Mice," Science, (1993) 261, 1584-1588.
Korsmeyer, S.J., "Bcl-2: An Antidote to Programmed Cell Death," Cancer Surveys, (1992) 15, 105-118.
Korsmeyer, S.J., "Bcl-2: a repressor of lymphocyte death," Immunology Today, (1992) 13, 285-288.
McKearn et al. (1985) Proc. Nat. Acad. Sci., U.S.A., 82: 7414-7418.
Lipford et al. (1987) Blood 70: 1816-1823.
Cleary et al. (1986) Cell 47: 19-28.
Kozopas et al. (1993) Proc. Nat. Acad. Sci., U.S.A. 90: 3516-3520.
Yin et al. (1994), "BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax," Nature 369:321-323.
Yin et al. (1993), "BCL-2 functions by counteracting its dimerization partner, Bax, a death accelerator protein," Blood 82(10):441A, abstract No. 1749.

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