Cell death regulator

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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435 71, 435 72, 435 721, 435 731, 435 78, 4352401, 4352402, 435 691, 4351723, 530350, 436501, C12Q 168, G01N 3368, G01N 3353, C12P 2102, C12N 502, C12N 512, C07K 14475

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057006385

ABSTRACT:
The invention provides a bcl-2 related protein, bcl-2 muteins, and uses thereof.

REFERENCES:
patent: 5283173 (1994-02-01), Fields et al.
Cleary et al. (1986) Cloning And Structural Analysis Of cDNAs For bc1-2 And A Hybrid bc1-2/Immunoglobulin Transcript Resulting From The t(14;18) Translocation, Proc. Natl. Acad. Sci. USA 47: 19-28.
Hockenbery (1990), Bc1-2 Is An Inner Mitochondrial Membrane Protein That Blocks Programmed Cell Death, Nature 348:334-336.
Hockenbery (1991), Bc1-2 Protein Is Topographically Restricted In Tissues Characterized By Apoptotic Cell Death, Proc. Natl. Acad. Sci. USA 88:6961-6965.
Korsmeyer (1992), Bc1-2 Initiates A New Category Of Oncogenes: Regulators Of Cell Death, Blood 80:4, 879-886.
Korsmeyer (1992), An Antidote To Programmed Cell Death, Cancer Surveys 15:105-118.
Korsmeyer (1992), Bc1-2: A Repressor Of Lymphocyte Death, Immunology Today 13: 285-288.
Kozopas et al. (1993), MCLI, A Gene Expressed In Programmed Myeloid Cell Differentiation, Has Sequence Similarity To BCL2, Proc. Natl. Acad. Sci. USA 90:3516-3520.
Lipford et al. (1987), Refinement of Lymphoma Cytogenetics By The Chromosome 18q21 Major Breakpoint Region, Blood 70:1816-1823.
McDonnell et al. (1990), Deregulated Bc1-2-Immunoglobulin Transgene Expands A Resting But Responsive Immunoglobulin M And D-Expressing B-Cell Population, Mol. & Cell Biol. 10:5, 1901-1907.
McDonnell et al. (1991), Progression From Lymphoid Hyperplasia To High-Grade Malignant Lymphoma In Mice Transgenic For The t(14;18), Nature 349:254-256.
McDonnell et al. (1989), bcl-2-Immunoglobulin Transgenic Mice Demonstrate Extended B Cell Survical And Follicular Lympho-Proliferation, Cell 57:79-88.
McKearn et aL. (1985), Enrichment of Hematopoietic Precursor Cells And Cloning Of Multipotential B-Lymphocyte Precursors, Proc. Natl. Acad. Sci. USA 82:7414-7418.
Nakayama (1993), Disappearance Of The Lymphoid System In Bc1-2 Homozygous Mutant Chimeric Mice, Science 261:1584-1588.
Nunez et al. (1990), Deregulated Bc1-2 Gene Expression Selectively Prolongs Survival Of Growth Factor-Deprived Hemopoietic Cell Lines, J. Immun. 144:9, 3602-3610.
Nunez et al. (1991), Bc1-2 Maintains B Cell Memory, Nature 353: 71-73.
Sentman (1991), bc1-2 Inhibits Multiple Forms Of Apoptosis But Not Negative Selection In Thymocytes, Cell 67:879-888.
Silverman et aL. (1990), Meiotic Recombination Between Yeast Artificial Chromosomes Yields A Single Clone Containing The Entire BCL2 Protooncogene, Proc. Natl. Acad. Sci USA 87:9913-9917.
Yin et al. (1993), BCL-2 Functions By Counteracting Its Dimerization Partner, BAX, A Death Accelerator Protein, Blood 82:441A, Abstract No. 1749.
Yin et al. (1994), BH1 And BH2 Domains Of Bc1-2 Are Required For Inhibition Of Apoptosis And Heterodimerization With BAX, Nature 369:321-323.
Young et al. (1993), A Negative Regulatory Element In The bc1-2 5'-Untranslated Region Inhibits Expression From An Upstream Promoter, Mol. & Cell Biol. 13:6, 3686-3697.
Zutter et al. (1991), Immunolocalization Of The Bc1-2 Protein Within Hematopoietic Neoplasms, Blood 78:4, 1062-1068.
Fields et al (1989) A novel genetic system to detect protein-protein interactions. Nature 340:245-246.
Chien et al. (1991) The two-hybird system: a method to identify and clone genes for proteins that interact with a protein of interest. Proc. Natl. Acad. Sci., USA 88:9578-9582.

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