Cell death protein

Details Cell death protein Cell death protein

1995-05-18

1997-10-07

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

536 231, 536 235, 536 234, 435 691, 435 699, 435183, 530350, C12N 120, C07H 2102, C07H 2104, C12P 2106

Patent

active

056747349

ABSTRACT:
Disclosed is a protein, designated RIP, which contains a death domain at its carboxy terminus and a kinase domain at its amino terminus. RIP interacts with the Fas/APO-1 intracellular domain and the TNFR1 intracellular domain. When expressed in transformed host cells, recombinant RIP promotes apoptosis. Also disclosed are DNA molecules encoding RIP, anti-RIP antibodies, and screening methods for discovering inhibitors of RIP-dependent apoptosis.

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