Cell death inducers for mast cells

Details Cell death inducers for mast cells Cell death inducers for mast cells

2007-05-15

2007-05-15

Carlson, Karen Cochrane (Department: 1656)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S325000, C435S252300, C435S320100, C536S023100, C530S350000

Reexamination Certificate

active

10482793

ABSTRACT:
A cell death inducer for mast cells, a preventive/therapeutic agent for diseases in which mast cells are implicated, having a fusion protein including a PTD and an MITF variant as an active ingredient and a fusion protein comprises a His Tag, a PTD, and an MITF variant, wherein the MITF variant being an MITF mi variant, wh variant, HLH fragment, or A-type N-terminal region (1-305) fragment, and the PTD being a TAT-derived peptide; DNA coding for the fusion protein; and a method for preparing the fusion protein using genetic engineering techniques. Actions of the fusion protein of the present invention include inhibiting an activity of endogenous MITF by translocating into mast cells, inhibiting a survival of mast cells derived from precursor cells, and inducing cell death (apoptosis) in mature mast cells.

REFERENCES:
patent: WO 01/66735 (2001-09-01), None
Supplementary Partial European Search Report for EP 02 74 3832 dated Mar. 1, 2005.
Tsujimura et al., “Involvement of Transcription Factor Encoded by the MousemiLocus (MITF) in Apoptosis of Cultured Mast Cells Induced by Removal of Interleukin-3,” American Journal of Pathology, vol. 151, No. 4, pp. 1043-1051 (Oct. 1997).
Nagahara et al., “Transduction of Full-Length TAT Fusion Proteins into Mammalian Cells: TAT-p27KiplInduces Cell Migration,” Nature Medicine, vol. 4, No. 12, pp. 1449-1452 (Dec. 1998).
Kitamura et al., “mi-Transcription Factor as a Regulator of Mast Cell Differentiation,” International Journal of Hematology, vol. 71, No. 3, pp. 197-202 (Apr. 2000).
Hodgkinson, et al., “Microphthalmia-Associated Transcription Factor,” 4 pages (Oct. 1, 2000) (Abstract).

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