Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1993-09-17
1997-01-14
Wax, Robert A.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
4352523, 43525411, 4353201, 536 235, C12N 100, C12N 510, C12N 1512, C12N 1563
Patent
active
055938795
ABSTRACT:
The present invention relates to cell death genes, which are genes required for programmed cell deaths; mutant organisms, in which embryonic programmed cell death occurs to a less than normal extent; proteins encoded by the cell death genes; antibodies which bind the cell death gene products; and agents which alter the ability of cell death genes to cause programmed death of cells. As described herein, Applicants have identified two genes which function in the initiation of apoptosis or programmed cell death. These two genes, referred to respectively as the reaper (rpr) gene and the head involution defective (hid) gene, map to position 75C1,2 on the third chromosome in Drosophila (D.) melanogaster and, as described in detail below, exhibit expression patterns related to the pattern of cell death during Drosophila embryogenesis; mutations in each gene reduce levels of cell deaths or abolish cell death.
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Abrams John M.
Grether Megan E.
Steller Hermann
White Kristin
Bugaisky G. E.
Massachusetts Institute of Technology
Wax Robert A.
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