Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-07-22
2010-06-29
Carlson, Karen Cochrane (Department: 1656)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S325000, C435S252300, C435S320100, C536S023100
Reexamination Certificate
active
07745123
ABSTRACT:
The present invention relates to non-destructive and dynamic means for determining the cell cycle position of living cells. The invention provides stable cell lines which can be used to determine the cell cycle position, together with methods for measuring the effect of a test agent on the cell cycle position.
REFERENCES:
patent: 4683202 (1987-07-01), Mullis
patent: 5288641 (1994-02-01), Roizman
patent: 6048693 (2000-04-01), Bitter
patent: 6159691 (2000-12-01), La Thangue et al.
patent: 7235401 (2007-06-01), Pines et al.
patent: 0 798 386 (2004-05-01), None
patent: WO03/031612 (2003-04-01), None
Gu, J., et al., “Cell Cycle-dependent Regulation of a Human DNA Helicase that Localizes in DNA Damage Foci”, Molecular Biology of the Cell, vol. 15, 2004, p. 3320-3332.
Filhol, O., et al., “Live-Cell Fluorescence Imaging Reveals the Dynamics of Protein Kinase CK2 Individual Subunits”, Molecular and Cellular Biology, vol. 23, No. 3, 2003, p. 975-987.
Oakley, R., et al., “The Cellular Distribution of Fluorescently Labeled Arrestins Provides a Robust, Sensitive, and Universal Assay for Screening G Protein-Coupled Receptors”, Assay and Drug Development Technologies, vol. 1, No. 1-1, 2002, p. 21-30.
Flatt, P., et al., “Mechanisms of Cell-Cycle Checkpoints: At the Crossroads of Carcinogenesis and Drug Discovery”, Drug Metabolism Reviews, (2000), 32(3&4), 283-305.
Buolamwini, J., “Cell Cycle Molecular Targets in Novel Anticancer Drug Discovery”, Current Pharmaceutical Design, (2000), 6, 379-392.
Barlogie, B., et al., “Flow Cytometry in Clinical Cancer Research”, Cancer Research, (1983), 43(9), 3982-3997.
Pines, J., “Four-Dimensional Control of the Cell Cycle”, Nature Cell Biology, (1999), 1, E73-E79.
Kohn, K., “Molecular Interaction Map of the Mammalian Cell Cycle Control and DNA Repair Systems”, Molecular Biology of the Cell, (1999), 10, 2703-2734.
Herman, C., “Cytometric DNA Analysis in the Management of Cancer”, Cancer, (1992), 69(6), 1553-1556.
Hauser, M., et al., “Histochemical Analysis of Root Meristem Activity inArabidopsis thalianaUsing a Cyclin:GUS (β-glucuronidase) Marker Line”, Plant and Soil, (2000), 226, 1-10.
Brandeis, M., et al., “The Proteolysis of Mitotic Cyclins in Mammalian Cells Persists from the End of Mitosis Until the Onset of S Phase”, The EMBO Journal, (1996), 15(19), 5280-5289.
Jones, J., et al., “Probing the Precision of the Mitotic Clock with a Live-Cell Fluorescent Biosensor”, Nature Biotechnology, (2004), 22(3), 306-312.
Labas, Y., et al., “Diversity and Evolution of the Green Fluorescent Protein Family”, PNAS, (2002), 99(7), 4256-4261.
Tsien, R., “The Green Fluorescent Protein”, Annual Reviews Biochemistry, (1998), 67, 509-544.
Rittinger, K., et al., “Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding”, Molecular Cell, (1999), 4, 153-166.
Jang, S., et al., “A Segment of the 5′ Nontranslated Region of Encephalomyocarditis Virus RNA Directs Internal Entry of Ribosomes During In Vitro Translation”, Journal of Virology, (1988), 62(8), 2636-2643.
Sambrook, J., et al., Molecular Cloning—A Laboratory Manual, Cold Spring Harbor Laboratory Press, 1982.
Beaucage, S., et al., “Deoxynucleoside Phosphoramidites—A New Class of Key Intermediates for Deoxypolynucleotide Synthesis”, Tetrahedron Letters, (1981), 22(20), 1859-1862.
Matthes, H., et al., “Simultaneous Rapid Chemical Synthesis of Over One Hundred Oligonucleotides on a Microscale”, The EMBO Journal, (1984), 3(4), 801-805.
Saiki, R., et al., “Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase”, Science, (1988), 239, 487-491.
Tur-Kaspa, R., et al., “Use of Electroporation to Introduce Biologically Active Foreign Genes into Primary Rat Hepatocytes”, Molecular and Cellular Biology, (1986), 6(2), 716-718.
Potter, H., et al., “Enhancer-dependent Expression of Human K Immunoglobulin Genes Introduced into Mouse pre-B Lymphocytes by Electroporation”, (1984), 81, 7161-7165.
Graham, F., et al., “A New Technique for the Assay of Infectivity of Human Adenovirus 5 DNA”, Virology, (1973), 52, 456-467.
Rippe, R., et al., “DNA-Mediated Gene Transfer into Adult Rat Hepatocytes in Primary Culture”, Molecular and Cellular Biology, (1990), 10(2), 689-695.
Stewart, M., et al., “Gene Transfer In Vivo with DNA-Liposome Complexes: Safety and Acute Toxicity in Mice”, Human Gene Therapy, (1992), 3, 267-275.
Torchilin, V., et al., “Targeted Accumulation of Polyethylene Glycol-Coated Immunoliposomes in Infarcted Rabbit Myocardium”, FASEB J., (1992), 6, 2716-2719.
Zhu, N., et al., “Systematic Gene Expression After Intravenous DNA Delivery into Adult Mice”, Science, (1993), 261, 209-211.
Ledley, F., “Somatic Gene Therapy for Human Disease: Background and Prospects”, The Journal of Pediatrics, (1987), 110(1), 1-8.
Nicolau, C., et al., “In Vivo Expression of Rat Insulin after Intravenous Administration of the Liposome-Entrapped Gene for Rat Insulin I”, PNAS, (1983), 80, 1068-1072.
Nicolau, C., et al., “Liposome-Mediated DNA Transfer in Eukaryotic Cells—Dependence of the Transfer Efficiency Upon the Type of Liposomes Used and the Host Cell Cycle Stage”, Biochimica et Biophysica Acta, (1982), 721, 185-190.
Jiao, S., et al., “Particle Bombardment-Mediated Gene Transfer and Expression in Rat Brain Tissues”, Biotechnology, (1993), 11, 497-502.
Miller, A., “Retroviral Vectors”, Current Topics in Microbiology and Immunology, (1992), 158, 1-24.
Baichwal, V., et al., “Vectors for Gene Transfer Derived from Animal DNA Viruses: Transient and Stable Expression of Transferred Genes”, in Gene Transfer, ed. R. Kucherlapati, New York, Plenum Press, (1986), 117-148.
Muzyczka, N., “Use of Adeno-Associated Virus as a General Transduction Vector for Mammalian Cells”, Current Topics in Microbiology and Immunology, (1992), 158, 97-129.
Krasagakis, K., et al., “Growth and Characterization of a Cell Line from a Human Primary Neuroendocrine Carcinoma of the Skin (Merkel Cell Carcinoma) in Culture and as Xenograft”, Journal of Cellular Physiology, (2001), 187(3), 386-391.
Paris, S., et al., “A Model of Spontaneous Lung Metastases Visualised in Fresh Host Tissue by Green Fluorescent Protein Expression”, Clinical and Experimental Metastasis, (1999), 17(10), 817-822.
Pye, D., et al., “Dermal Fibroblasts Participate in the Formation of New Muscle Fibres when Implanted into Regenerating Normal Mouse Muscle”, Journal of Anatomy, (2001), 198(Pt 2), 163-173.
Brod, S., et al., “Ingested Interferon-α Prevents Allograft Islet Transplant Rejection”, Transplantation, (2000), 69(10), 2162-2166.
Terskikh, A., et al., “Fluorescent Timer: Protein that Changes Color with Time”, Science, (2000), 290, 1585-1588.
Boyle, W., et al., “Phosphopeptide Mapping and Phosphoamino Acid Analysis by Two-Dimensional Separation on Thin-Layer Cellulose Plates”, Methods in Enzymology, (1991), 201, 110-149.
Voitenleitner, C., et al., “Cell Cycle-Dependent Regulation of Human DNA Polymerase α-Primase Activity by Phosphorylation”, Molecular and Cellular Biology, (1999), 19(1), 646-656.
Nelms, B., et al., “In Situ Visualization of DNA Double-Strand Break Repair in Human Fibroblasts”, Science, (1998), 280, 590-592.
Van Den Bosch, M., et al., “The MRN Complex: Coordinating and Mediating the Response to Broken Chromosomes”, EMBO Reports, (2003), 4(9), 844-849.
Gorlich, D., et al., “Transport Between the Cell Nucleus and the Cytoplasm”, Annu. Rev. Cell Dev. Biol.,
Fanning Ellen
Gu Jinming
Hancock Suzanne
Stubbs Simon
Thomas Nicholas
Carlson Karen Cochrane
GE Healthcare UK Limited
Ji Yonggang
Vanderbilt University
LandOfFree
Cell cycle reporting cell line does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cell cycle reporting cell line, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cell cycle reporting cell line will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4190102